The giants remaining in the FA Cup have avoided each other in the quarter-final draw made by England coach Gareth Southgate on Thursday evening.
The lowest-ranked team remaining in the competition, Boreham Wood from the National League, could play Crystal Palace if they beat Everton.
Liverpool will travel away to take on a Championship team, which will be either Nottingham Forest or Huddersfield Town after they play on Monday.
Another second-tier side, Middlesbrough, will welcome Chelsea to Riverside, with all of the lower-division teams already qualified being drawn at home.
Southampton and Manchester City will face off in the only guaranteed all-Premier League clash, with Pep Guardiola’s side needing better than their 1-1 draw in January.
The sixth round of the FA Cup will take place over the weekend between Friday, March 18, and Monday, March 21.