Osimhen has missed Galatasaray’s last two matches, including their Champions League defeat to Union Saint-Gilloise, due to injury.
The 26-year-old striker sustained the injury while playing for Nigeria during the last international break.
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Speaking to Ekol TV, Özbek said Osimhen has returned from injury, and he will be part of the squad that will play against Fenerbahçe.
“Osimhen will be in the squad. He was the target,” Özbek said.
“Our other players who have returned from injury will most likely be in the squad as well. We will field a very good team.”
Osimhen has been impressive for Galatasaray so far this season in all competitions.