Tag: DNA

  • Gates, Bezos fund new cancer test with $100m

    Bill Gates and Jeff Bezos have invested more than 100 million dollars in a new cancer test.

    Grail, the company developing the test, said on Tuesday in Beijing that the method was a universal blood test to identify early-stage cancers in people with no symptoms.

    Jay Flatley, Illumina Chief Executive, who would serve as chairman of Grail, said the technology was aimed at detecting newly-forming cancers, and treat them at an earlier stage to increase the chances of survival.

    He said the company started this new test 18 months ago, and that it was estimated to take at least an additional year of research and development to refine it.

    Flatley said the process was being carried out through a technique called a “liquid biopsy’’.

    “It scans patients’ blood streams for signs of cancer DNA, which can indicate that a tumor is forming, even if a doctor can’t see it on a scan and the patient hasn’t experienced any symptoms,” he said.

  • DNA repairs’ discoverers win Nobel prize in Chemistry

    The 2015 Nobel prize in Chemistry has been awarded to the discoverers of DNA repairs.

    Tomas Lindahl and Paul Modrich and Aziz Sancar were named as the winners yesterday morning at a news conference in Stockholm, Sweden.

    Their work uncovered the mechanisms used by cells to repair damaged DNA – a fundamental process in living cells and important in cancer.

    Prof Lindahl is Swedish, but has worked in the UK for more than three decades.

    The prize money of eight million Swedish kronor (£634,000; $970,000) will be shared among the winners.

    “It was a surprise. I know that over the years I’ve occasionally been considered for a prize, but so have hundreds of other people. I feel lucky and proud to be selected today,” Lindahl, from the UK’s Francis Crick Institute, told reporters.

    Claes Gustafsson, from the Nobel Committee, said the recipients had “explained the processes at the molecular level that guard the integrity of our genomes.”

  • Understanding the DNA test result

    Understanding the DNA test result

    The DNA test compares the sizes of chosen genetic markers between the samples being investigated.  Each DNA marker contains two alleles, one inherited from the biological mother and the other from the biological father. The DNA test finds out whether there is at least one match out of the two alleles on the same marker from the compared samples. In a Paternity test, the Paternity Index (PI) is a statistical measure of how strongly a match using a particular marker indicates paternity.

    The PI’s of the markers are multiplied with each other to generate the Combined Paternity Index (CPI).  This gives “the overall probability of an individual being the biological father of the tested child relative to any random man from the entire population of the same race.” (Universal Genetics DNA Testing Laboratory).  “The CPI is then converted into a Probability of Paternity showing the degree of relatedness between the alleged father and child.”

    Universal Genetics DNA Testing Laboratory, for example, “ always achieves a 0% probability of paternity if the tested man is not the biological father and at least 99.9% probability of paternity if the tested man is the biological father. Both results are conclusive to prove or disprove paternity.”

    Universal Genetics DNA Testing Laboratory, as a standard laboratory, also issues a Chain-of-Custody Testing Result.  The customer receives the following information:

    1. All tested parties’ names as shown on their IDs presented at specimen collection
    2. Listing of each tested party’s individual DNA profile
    3. A Combined Paternity Index
    4. A Probability of Paternity
    5. A statement of conclusion
    6. Copy of chain-of-custody documents including clients’ IDs, consent forms, and photos.

    SOME COMMON USES OF LEGAL PATERNITY TESTS

    In a world of poverty, too many women are abandoned to struggle alone with providing all that it takes for a child to survive and even thrive.  The child’s father is comfortably at large enjoying his own life in “peace”.

    It often happens in Nigeria and other parts of the world that when a well-to-do man dies, there is confusion and strife over sharing of his property.  Questionable claimers arise from nowhere insisting on their “inheritance”.  Indeed some of them appear with physical semblance to the deceased to the shock of the known and established relations.

    Some babies unfortunately are born with no name of Father for their birth certificates.

    Child support claims, determining eligibility for inheritances, and listing a father’s name on a birth certificate are recognized common uses of paternity tests.  These issues can be resolved through a Legal DNA Paternity Test.  A legal DNA paternity test costs more than a non-legal DNA paternity test due to the additional requirements involved.

    A non-legal paternity test is also known as a home or peace-of-mind paternity testand does not need official notarization.  You can do it yourself by purchasing a home DNA paternity test online.  From the kit sent to you, you collect the specimens by simply rubbing a swab on the inside of your cheek as well as that of other parties to be compared in the test. You mail back to the lab all the swabs in sample envelopes following instructions provided.  The results will include the same information as a legal DNA paternity test without notarization. Typically, it takes under a week for the lab to complete the job. Non-legal paternity tests, though accurate, cannot be used in court.  If you want to present in court, ask for a Legal Paternity Test. (to be concluded).

     

    Dr. ‘Bola John is a biomedical scientist based in Nigeria and in the USA.   For any comments or questions on this column, please email bolajohnwritings@yahoo.com or call 08160944635

  • How does DNA testing work?

    How does DNA testing work?

    DNA testing is also called DNA typing, DNA profiling, genetic fingerprinting, genotyping, or identity testing.The procedure involves isolating and identifying variable elements within the base-pair sequence of DNA (deoxyribonucleic acid).

    Forensic DNA analysis (usually analysis of short tandem repeats (STRs)) uses the polymerase chain reaction (PCR),gel electrophoresis, and detection.

    This is how crime and accident scenes DNA evidences are used for detecting criminals, identifying missing persons, identifying corpses, for post-conviction testing, for repealing wrongful convictions, and for clarifying familial ties and disputes.

    A fetish Nigerian restaurant was caught serving human meat.   Some big business scammers were found adding horsemeat to their “beef” products.  These are cases where DNA testing is useful. DNA testing is also used for food testing,  fordesigning drought-resistant plants, and for producing biological drugs from genetically altered bacteria.

    POLYMERASE CHAIN REACTION (PCR).

    To prepare for PCR, DNA is isolated from a sample in a multi-step process that may be done manually or with an instrument such as the COBAS® AmpliPrep Instrument. PCR takes place in a bench-top equipment called a thermocycler and involves thefollowing steps.

                 Denaturing: during this process the temperature is increased to separate the strands.

                 Annealing: during this process the temperature is decreasedto allowprimerstopairtocomplementary DNA templates. (Primers determine the DNA sequence to be amplified.)

                 Extension: during this process the enzyme called polymerase extends the primer to form new DNA strands.

                 Exponential amplification: the cycle is repeated and existing DNA strands are copied to form new DNA strands.

    The varied length strands are then separated by gel electrophoresis.

    GEL ELECTROPHORESIS

    Gel electrophoresisis a process that is used to separate proteins and nucleic acids that differ in size.

    In the process of DNA testing, DNA fragments cut by restriction enzymes are separated based on their rate of movement through a porous gel in an electric field. The prepared DNA samples are loaded into small wells at one end of the gel from where they travel towards the other end of the gel.  The gel is immersed in a buffer solution within a chamber between two electric nodes.  An electric current is applied and compels thenegatively charged DNA fragment to move towards the positively charged end of the gel.  The distancealong the gel that a DNA molecule travels is inversely proportional to its length. The smaller strands travel faster to the other end of the gel by electrical attraction. The separated proteins appear as bands within the gel, each band representing a certain molecular size, but are invisible within the gel.

    After the current is turned off, a dye is added to reveal the separated bandswhich are made to fluoresce in ultraviolet light or when passed through a laser.Somemethods of detection capture imprints of the separated bands on an X-ray film. Newer methods use DNA reads on a computer screenandcomputerprint-outs.

    In industrial-type speedy automatic sequencing machines, a complex set of procedures is used to prepare DNA for sequencing. ”When DNA is finally in a form that the machines can read, it has been chopped up, copied, chemically modified, and tagged with fluorescent dyes corresponding to the four different DNA bases, or genetic letters.”

    Http://www.genomenewsnetwork.org/resources/whats_a_genome/Chp2_2.shtml

     

    Dr. ‘Bola John is a biomedical scientist based in Nigeria and in the USA.   For any comments or questions on this column, please email bolajohnwritings@yahoo.com or call 08160944635

  • How DNA testing is done

    How DNA testing is done

    For more details about this topic please visit “How stuff works” by William Harrisat http://science.howstuffworks.com/life/genetic/dna-evidence.htm.

    Previously, fingerprints were the gold standard for identifying a person.  Presently, DNA testing tops the list of the forensic methods used for criminal investigation, disaster victim identification, and missing persons investigations. The techniques involved in DNA testing have been used since 1985. Alec Jeffreys and his colleagues in Englandwere the first to demonstrate the use of DNA in a criminal investigation. DNA testing now plays a role in many nations’ criminal justice systems.Presently,legislations in many countries of the world supportthe establishment of National DNA databases.Public laboratories are linked to law enforcement  ordistrict attorneys.Some private forensic laboratoriesexist solely for DNA analysis.

    DNA testing is delicate, precision work and needs a proper set-up, proper expertise, and secure financing. The biologic sample or item on which DNA could be found is collected, the DNA is extracted, amplified, and the profiling in done and interpreted.Samples include biologic materials such as saliva, semen, urine, blood, hair, and nail cuttings.Many labs conduct testing on nuclear DNA, the DNA that exists in the nucleus of every cell.  Fewer labs have specialized techniques such as Y-chromosome or mitochondrial DNA analysis. Here we discussvariousDNA techniques.

    Restriction fragment length polymorphism (RFLP) analysis was one of the first forensic methods used to analyze DNA. It analyzes the length of strands of DNA that include repeating base pairs. These repetitions are known as variable number tandem repeats (VNTRs) because they can repeat themselves one to 30 times.

    For RFLP analysis, investigators dissolve DNA in an enzyme medium that breaks the strand at specific points or loci. The number of repeats affects the length of each resulting strand of DNA. Investigators compare the lengths of the derived strands from samples in question e.g., .the different samples from suspect persons. RFLP analysis requires a fairly large sample of DNA that hasn’t been contaminated with dirt.

    Many laboratories have replaced RFLP analysis with short tandem repeat (STR) analysis. One of the advantages of this method is that it can start with a much smaller sample of DNA. Scientists amplify this small sample through a process known as polymerase chain reaction (PCR). In the laboratory, PCR is used to make copies of the DNA mimicking how DNA copies itself in a living cell.  As in the cell, the existing DNA is unwound and the ladder is split to form templatesfrom which nucleotide sequences arereverse copied as enzymes direct nucleotides to join complementary nucleotides in a chain reaction.  The copy strands are themselves copied and so amplification goes on by continuous copying of increasing copies.  By this, any required amount of the DNA can be artificially produced in the lab through amplification of a trace sample to provide enough samplefor the testing procedure.  This is how DNA testing has been possible starting from trace samplesor low level amountsfrom such items as chewing gum, cigarette butts, or a used spoon or drinking straw.Invisible samples from objects (touched by a suspect or a person of interest) are swabbed or taped off from items such as food, clothing, bedding, carpets, knives and other tools, vehicles, guns, cosmetics, wallets, jewelry, surfaces, paper, doors, etc.  Improved methods are allowing scientists to even obtain DNA from old, burnt, or degraded bone and tissue samples.  Samples not less than 200 picograms(200 x 10−12 g) are usable.   A picogram isone millionth of one millionth of a gram therefore trace DNA testing is a magical phenomenon.

    In many cases, trace DNA has been the key evidence for identifying a person of interest or that produced justice for an offender.  The world is entering a stage where, really, we all have to behave ourselves, if not for fear of God, for fear of DNA.

    After amplifying the DNA, STR analysis is used to determine how often base pairs repeat in specific loci on a DNA strand. They are called dinucleotide, trinucleotide, tetranucleotide or pentanucleotide repeats for repetitions of two, three, four or five base pairs respectively. Thetetranucleotide or pentanucleotide repeats are preferred for accuracy.  There is a consensus set of core STR lociwhich allows comparisons of profiles across government jurisdictions and over time through use of national databases.

    As great as DNA testing is, you do not have to just swallow any lab result.  ”In placing a profile obtained from trace amounts of biological material found at the crime-scene into context, the analyst should take into account the potential for transfer of the material, the possible cellular origin of the DNA profile in question, the stochastic nature of the collection and analytical procedures and the possibility of artefacts confounding the true result. In most laboratories the analytical methods and statistical calculations employed for standard DNA typing are used for trace DNA – a process which is statistically and scientifically incorrect and which can bias calculations heavily against the defendant” (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012025/).There are interpretation methods specific for trace DNA.To be continued.

    Dr. ‘Bola John is a biomedical scientist based in Nigeria and in the USA.   For any comments or questions on this column, please email bolajohnwritings@yahoo.com or call 08160944635

  • DNA Testing: Ignorance in bliss or peace of mind in knowing

    DNA Testing: Ignorance in bliss or peace of mind in knowing

    Continued from last week

     

    ”Today, more than half of all births from American women under 30 occur outside of marriage. Increases in births outside of the marriage may point to the transforming family. Today, technology has equipped women bearing children with non-invasive DNA paternity tests that will help answer the question, who is the father?” (http://www.dnacenter.com/blog/im-pregnant-who-is-the-father-dna-paternity-testing/).

    Social life in these times has brought about issues that require application of science and technology.  Premarital, extramarital, and non-marital sexual affairs are perhaps much more common in this nascent century than they were in the last century as the world has undergone a type of sexual revolution that opposes traditional concepts based on the major world religions.

    Whether to catch criminals or to determine paternity, or for a host of other uses, DNA testing has come to stay.  The average man thus needs to know what DNA is and what can be obtained with DNA testing.

    Before you think it does not concern you, let us take a few scenarios.  Jack had a girlfriend who was his colleague in their days at university.  He denied that her pregnancy back then was his.  He married another woman and was happy with his family and executive job until his old girlfriend showed upten years later.  Her private investigator succeeded in getting a DNA test done to prove Jack’spaternity of her child.  She not only got child support from him but sued him on many counts including psychological damage and setback in her own life due to his abandonment of the child. Jack’s wife was upset by the drama and did not want to live with a virtual other wife feeding off her husband. She quit with her own children.  With DNA testing, things can return to haunt a happy marriage or a happy life.Men could be easily set-up by predator women who would drag them to court and win their money and estates.

    Youths often get into trouble by being at the wrong place or somewhere at the wrong time.  I was talking to a man a few days ago.  He was released from prison six months ago. He spent 27 years in maximum security prisons.  He was locked up before DNA testing was introduced. He was saved by an NGO that took care of convicts claiming innocence.  Now his DNA did not match the DNA of the criminal. There may be many other innocents suffering miscarriage of justice and waiting for freedom, perhaps in vain.

    DNA can be used in evil ways. An innocent person’s DNA can be placed in a crime scene or planted for dubious reasons.  Your DNA can be used against you.  Big-time criminals that get your DNA information or the DNA information of your loved ones can use it to begin rumors about you, blackmail you, extort money from you, etc.  Enemies can use your DNA information to socially sabotage you.  Capitalists can use DNA information unethically to target particular persons for lucrative goals or exploitation.

    DNA testing can lead to people playing God.  People secretly DNA-testing other people can become oppressors and repressors. A man is so convinced that that girl will have an ugly cancer that he does not allow his son to marry her and his son, instead, goes and marries a DNA-perfect demoniac. Big Business is so convinced that some persons are schizophrenic type that they are not given jobs or if they have jobs, they are not allowed to get promoted. Big Brother governments can begin to control people’s lives, manipulate, determine, discriminate, segregate, etc.

    The normal person strives for health in body, mind, and spirit.  DNA testing only gives a probability that rationality takes seriously and faith takes peacefully.  The power of reasoning and the power of prayer are needed by the average man. Faith and reason are two sides of a coin that the present-day human being should know how to spend if he or she wants to live his/her best life.  We can avoid counterfeit currency.

    Today’s world easily crushes naïvetés. We can know how to “watch and pray”, as the Master teacher Jesus warned.  To watch is to learn and understand (not to spy) the pertinent things that are for our salvation. We therefor will discuss: What is DNA? How does DNA testing work? What is DNA testing used for?DNA-testing kits and services.  It is a lot of science for those who are not inclined to science but we shall discuss because we are all inclined to salvation.

    Dr. ‘Bola John is a biomedical scientist based in Nigeria and in the USA.   For any comments or questions on this column, please email bolajohnwritings@yahoo.com or call 08160944635

  • ‘Build healthcare capacity, infrastructure’

    There has been a call for Nigeria to build capacity and infrastructure in the health sector.

    According to the Chief Medical Director, Lagos University Teaching Hospital (LUTH), Prof. Akin Osibogun, this will ensure qualitative healthcare service delivery.

    Addressing the Advance Writing and Reporting Skills (AWARES) Class 14, Pan Atlantic University (PAU) students, who came on a facility tour of the hospital, Osibogun said the country was saved from an embarrassment when the Ebola virus broke out because of the LUTH/Chevron Genome/ Molecular Biology Research Laboratory, where the blood sample of the late Liberian-American, Mr Patrick Sawyer, who imported the Ebola Virus Disease (EVD) into Nigeria, was analysed.

    He said any form of delay in diagnosing the patient would have caused “a catastrophic situation”.

    He said the laboratory helped to save the situation.

    The community health expert, however, said healthcare cannot be totally free in Nigeria as somebody must pay for it, adding that people should separate politics from health financing.

    “If we are going to have the kind of healthcare that we have been longing for, then we have to finance it effectively,” he noted.

    Osibogun said the average per capita on health in Nigeria is less than N10,000 per person while that of United States is N1.3million. “In Europe is N800,000,” he noted.

    The government, he said, frowned at mass burial for victims of plane crash, especially the ill-fated Dana plane crash, which prompted the establishment of the facility in the hospital.

    He said the benefit of the DNA laboratory is huge as paternity and forensic issues can be carried out.

    A professor of haematology at the College of Medicine, University of Lagos, Sulaimon Akanmu said the centre has been involved in three researches, adding that this will help reposition the country in science.

    “This laboratory can help doctors know if a female child will have cancer at adulthood or whether a baby still in the womb will have sickle cell disease (SCD),” he said.

    Akanmu said Nigeria need to contribute to knowledge by engaging research and development. “Many opportunities have been lost because there was no conducive environment for research,” he said.

  • Africa’s Next Top Model premieres today

    Africa’s Next Top Model premieres today

    PLANS are currently being concluded to hold the premiere of the first season of reality model show, Africa’s Next Top Model, starting today, November 10. The programme is a television franchise format of America’s Next Top Model, created by American Supermodel, Tyra Banks, and will be hosted by international supermodel, Oluchi.

    Set in Cape Town, South Africa, the show features 12 girls from different parts of Africa competing for a chance to win the grand prize of a one-year modelling contract with New York-based modelling agency, DNA, a product endorsement deal and a cash prize of $50,000.

    Director, Brands and Communication at Etisalat Nigeria, sponsors of the show, Enitan Denloye, speaking on the company’s participation in the show, said it was a delight to be a part of a competition that promotes African beauty on an international platform. “The Africa’s Next Top Model reality search competition is uniquely different, in that it beams its searchlight on eight countries in Africa, giving an opportunity to a lot of young African supermodel hopefuls. We believe that this competition will discover and groom these girls that will enable them compete with their international counterparts,” he said.

    On Etisalat’s role in the competition and general proposition to the youth market, Denloye said the company is keeping true to its commitment of nurturing and celebrating talents. “At Etisalat we are distinguished by our innovative and unique approach to our business. We believe that our growth in the last five years is a testament to this. We will continually delight our customers with our world class standard products and services as well as our support of laudable initiatives such as the ANTM,” he said.

    The show features Aamito (Uganda), Cheandre (South Africa), Joyce (Nigeria), Marwa (Tunisia), Michaela (Angola), Michelle (South Africa), Omowunmi (Nigeria), Opeyemi (Nigeria), Rhulani (South Africa), Roselyn (Ghana), Safira (Mozambique) and Steffi (Kenya) as they strive to prove that they have what it takes to make it in the world of modelling.

  • How Nigeria can use DNA testing to curb crimes,by experts

    How Nigeria can use DNA testing to curb crimes,by experts

    INSPECTOR Charles Odigwe and Corporal Felix Egbosun were policemen attached to Ogidi Divisional Police Station in Anambra State.

    The two officers were dismissed from the Police Force in September 2010 for torturing 45-year-old Osita Okafor to death in a police cell.

    Okafor was away when his neighbour, Hyacinth Agbo, was arrested by some policemen for an alleged armed robbery offence.

    The policemen confiscated some property of Okafor, alleging that he was fingered in the robbery incident.

    When Okafor returned, he later went to the police station with his friend to reclaim his property but both of them were detained.

    Okafor later died from injuries inflicted on him by the two police officers in their attempt to extract information from him about the robbery.

    Observers maintain that stories like that of Okafor are commonplace in the country, as torture has somewhat become an acceptable means of extracting information from suspects.

    However, experts in cell biology and genetics insist that this should not be so since there are innovative methods of extracting information from suspects.

    The experts, at a recent DNA (deoxyribonucleic) forensics colloquium entitled “From Crime Scene to Courtroom: The DNA Evidence”, held at the University of Lagos, underscored the usefulness of DNA analysis in efforts to track down criminals.

    Prof. Bode Gbenle, who spoke on “DNA Fingerprinting in Forensic Science” noted that that DNA fingerprinting in forensic science, which started in the 19th Century in a laborious manual style, had now been made easier via the use of computers.

    “The advent of computers in the 1970s has made fingerprinting much easier, as the electronic process takes less time and produces more accurate matches.

    “The production of patterns of DNA bands that are unique to individuals make them useful in forensic examinations,” he said.

    Gbenle added: “What differentiates the chemical structure of everyone’s DNA from another is the order of the base pairs contained therein.”

    The professor stressed that it was the difference in the sequence of millions of base pairs in each person’s DNA that was unique, adding that it could also be used to distinguish one individual from another.

    “Scientists use a small number of sequences of DNA that are known to be different among individuals in a very clear manner; they analyse them to get a certain probability of a match,” he said.

    Prof. Oluseso Omidiji, who delivered a lecture on “DNA: The Molecule of Life”, said the human DNA was one part of the human life that remained for a long time.

    Omidiji, who is from the Department of Cell Biology and Genetics, University of Lagos, said contemporary crime detection procedures involved using some elements in human life, like the DNA.

    He underscored the need for such activities due to the fact that only living things could commit crimes.

    Omidiji said the DNA samples could be used in tracing criminals because they constituted an element in human life left at crime scenes.

    He said research had shown that the DNA contained materials that were very reliable in determining their sources of origin; adding, therefore, that the use of DNA analysis in crime investigations could exonerate or confirm the complicity of a suspect.

    Dr Mathias Okoye, the Director of Nebraska Forensic Medical Services in the U.S., stressed that Nigeria should not be left behind in the global efforts to acquire the DNA analysis technology.

    He noted that some smaller African countries had acquired the technology.

    “Laboratory procedures are very important in finding criminals because its results are usually more accurate. However, before you can use the technology effectively, you must have trained hands and relevant equipment to do quality forensic examination. To conduct quality forensic analysis, you need well-trained biochemists, who have expertise in protein biochemistry,” he said.

    Okoye, who is a medical doctor and forensic pathologist, warned that those who were not competent enough in carrying out DNA analysis should not be pushed into it so as to avoid any temptation to “cook up results”.

    He noted that before examining crime scenes for samples, investigators should first get preliminary information from callers and persons around the crime scene.

    Okoye, nonetheless, stressed that the investigators should be methodical in their documentation, adding that they should “examine blood stain patterns at the crime scene”.

    He emphasised that proper documentation would help the investigators to reconstruct the scene “in order to verify or contradict an alibi or testimony”.

    Okoye advised that before scaling up the practice of DNA analysis, the country should enact a “DNA Evidence and Allied Matters” legislation to take care of certain issues regarding human rights and standards which might crop up.

    The Vice-Chancellor of University of Lagos, Prof. Rahaman Bello, underscored the need for the establishment of a forensic institute in the university to train more experts in forensic biology.

    He also stressed the need to advance the knowledge of security agencies in forensic technology in order to boost crime detection in the country.

    The Executive Director, Inquaba Biotec of South Africa, Mr Oliver Preisig, said his company’s interest in co-sponsoring the colloquium was hinged on the need to expand knowledge of Nigerians in DNA analysis as this could help the country in crimes’ detection.

    All the same, stakeholders agree that Nigeria should commence extensive use of DNA analysis in its crime investigation efforts.

    They, however, stress the need for a proper legislation to take care of possible abuses.

  • ‘Why assisted reproduction is gaining ground’

    •Dr Ajayi (in tie) surrounded by his staff in celebration of the award

    Assisted reproduction is gradually being acceptable in the country because there are encouraging results, helping to crash the myths associated with it.

    The Managing Director, Nordica Fertility Centre, Dr Abayomi Ajayi said this while commending his staff for their devotion and professionalism that earned the centre the West Africa’s Best Healthcare Services Brand of the year, 2012. It was given by the African Business Marketing School under the Institute of Direct Marketing.

    Dr. Ajayi, the country’s representative of Obgyn.net, a network of obstetricians/gynaecologists all over the world, said the success story of Nordica Fertility Centre owes largely to the fact that it simplifies the terms and terminologies involved in the techniques and services involved in the assisted reproduction.

    “By word of mouth, everybody can communicate the basics to infertile couples, without misinforming them,” he said.
    For instance, women are often seen as being responsible for infertility in marriage. But the two sexes are responsible and must be examined so as to determine the cause and the treatment options available.

    “If you are planning to get pregnant, it’s important to consider ways to prevent infertility. Most women are unaware of how to avoid infertility. In fact, few women realise that their fertility clock winds down quickly, declining at around age 27. Surprisingly, the fertility clock declines for men, too. Studies show that men start losing their fertility as young as age 35.  Age is an important fertility consideration for both women and men,” said Dr Ajayi.

    Defining infertility, Dr Ajayi, a member of Global Health Council, said it is the inability of a person to contribute to conception. Those couples who are unable to conceive after 12 months of contraceptive-free intercourse, with the female partner being under the age of 34 should get themselves checked for fertility test.

    Dr Ajayi said: “An important preventable cause of testicular damage in men is uncorrected un-descended testes. Un-descended testes should be surgically treated at an early age to prevent damage, preferably before the age of two years. This requires educating mothers of young boys; and doctors as well. It may also be a good idea to immunise boys against mumps in childhood, thus preventing the ravage which mumps can cause to the testes in later life,” he said.

    The Clinic Manager, Nordica Fertility Centre, Tolani Ajayi said from interactions with clients, and based on clinical assessments, the issue of male infertility could also be traceable to occupational hazards.

    Mrs Ajayi said: “Occupational hazards can decrease sperm counts. Many toxic drugs including radiation, radioactive materials, anaesthetic gases, and industrial chemicals such as lead, the pesticide DBCP and the pharmaceutical solvent ethylene oxide can reduce fertility by impairing sperm production. Intense exposure to heat in the workplace, for example, long-distance truck drivers exposed to engine heat; and men working in furnaces or in bakeries, can cause long-term and even permanent impairment of sperm production.”

    The Clinic Manager said: “Drugs including alcohol, cocaine and marijuana – are all poisons. They can reduce sex drive; damage sperm production; and interfere with ovulation and sometimes this damage is irreparable. Smoking tobacco also affects reproductive function by depleting egg production; increasing the risk of Pelvic Inflammation Disease (PID); and lowering sperm counts. Often, the adverse effect is temporary, so that when these are stopped, the harmful effects on reproductive function are likely to be reversed. However, since abstinence is easier than moderation, the best option is not to smoke, drink or use drugs Wearing loose cotton underwear and trousers is advisable – tight clothes increase testicular temperature and may harm sperm production.”

    Dr Ajayi said: “Exposure to high temperatures on a continuous basis can also affect the sperm production and motility. It is important for men to protect the genital organs from excess heat. X-rays can be harmful to gonads. If X-rays are needed, the scrotum should be covered with a lead shield.

    “Exposure to pesticides, lead, heavy metals, toxic chemicals and ionizing radiations over a long time, reduces fertility in men.  Proper protective gear should be used to prevent such chemicals or rays affecting a man’s health especially reproductive health. Smoking has been found as a major culprit for low sperm counts and sluggish sperm movement in men. Alcohol also reduces sperm counts and can interfere with sexual performance. It may also disrupt hormone balances in women and increase the risk of miscarriage.”

    On the whole, Dr Ajayi, said there are bevavioural changes which can prevent infertility in men. “It is found that about forty percent of infertility is due to the man alone. Adopting healthy lifestyle can help in preventing infertility in men.
    “So it is advisable for a man to use multivitamin supplements which provides selenium, zinc and folic acid. These nutrients are important for optimising sperm production and function. Eat plenty of fresh fruits and vegetables which are rich in antioxidants. Such minerals help to improve sperm health. Reduce stress as stress might interfere with certain hormones needed to produce sperm. Get regular exercise to keep healthy and fit as proper blood circulation and functioning of glands are necessary for fertility.

    “Keep your weight in control as too much or too little body fat may disrupt production of reproductive hormones, which can reduce your sperm count. Quit using tobacco which can adversely affect fertility by producing inferior quality sperms. The sperm of men who smoke may be misshapen and may move more slowly than those of non smokers.Smoking can also damage your sperm’s DNA. Most importantly, be your own bodyguard to protect your fertility. Avoid lubricants during sex as even saliva can interfere with sperm motility. However, vegetable-oil-based lubricants are safe and can be used. You and your partner should be educated and aware of problems that can make pregnancy difficult,” said Dr Ajayi.