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Tag: Jobelyn

  • ‘Jobelyn can reverse stroke’

    The CEO/Managing Director of Health Forever Limited, Otunba Olajuwon Okubena, answers the question.

    Scientists from the Pharmacology Department of the University of Ibadan, led by Dr. Solomon Umukoro,have  demonstrated that Jobelyn, a Nigerian herbal product, has the potential to provide succour for stroke patients.

    This was contained in a recent article published in the journal Pathophysiology (ref https://www.ncbi.nlm.nih.gov/pubmed/30413288)and titled: ”Jobelyn ameliorates neurological deficits in rats with ischemic stroke through inhibition of release of pro-inflammatory cytokines and NF-K signaling pathway.”

    Their findings suggest that the positive effect of Jobelyn on neurological function in rats with ischemic stroke may be related to inhibition of oxidative stress, release of pro-inflammatory cytokines and expressions of other immune positive  cells.

    The scientists explained that Ischemic stroke is a fatal disease caused by sudden obstruction of cerebral blood flow with subsequent neuronal cell death ortissue necrosis. Occlusion of the blood vessels (carotid arteries) that supply blood to the brain and subsequent reperfusion are the critical factors involved in the pathology of ischemic stroke. Stroke is the second leading cause of death and disability worldwide.

    According to World Health Organisation (WHO), 15million people suffer from stroke worldwide each year, with over six million dying and more than half of the survivors being permanently disabled. The death rate due to the disease in most African countries is quite alarming resulting in huge loss of economic manpower and productivity.

    Moreover, stroke is typically associated with neurological deficits and the belief that the disease is incurable and even contributes to a wide range of psychiatric disturbances such as anxiety, depression and memory deficits. Over the past few decades, the understanding of the pathophysiology of stroke has increased but little progress has been made in the development of effective drugs for treatment of this debilitating disease.Current approach to the management of stroke focuses on the amelioration of symptoms as cure for the disease still remains elusive. The clinical efficacy of tissue plasminogen activators currently used for stroke has been compromised by serious adverse effects. Also, the need to administer them as quickly as possible, at least within three hours after onset of symptoms of the disease makes it almost unrealistic for patients in most African communities to benefit from these drugs.

    Moreover, the lack of accessibility to cost effective treatment for stroke is the major reason for the increased fatality and high burden of the disease in developing countries like most African nations.

    Jobelyn is a dietary supplement obtained from the polyphenol-rich leaf sheath of Sorghum bicolor (L) Moench(Poaceae). Sorghum bicolor is commonly known as millet and has been used in African traditional medicine for treatment of several diseases over hundred years ago. It is manufactured by Health Forever Products Limited, Lagos, Nigeria, and is available as capsules in most pharmaceutical outlets in Nigeria and abroad, including United States. It has gained high reputation as a remedy for treatment of moderate to severe anaemia. The manufacturer also claimed that the dietary supplement is beneficial in neurological disorders such as psychosis, stroke and convulsions. It is also known to boost the immune system, thereby enhancing the body’s defensive mechanisms in responseto stress, infections or debilitating diseases. The manufacturer recommends one or two capsules, one to three times per day for the treatment of anaemia. However, the manufacturer also recommends higher doses of Jobelyn for chronic diseases like cancer, arthritis and stroke. The major active phytochemical constituents found in Jobelyn and their mechanisms of action in neurological disorders were presented in the article.

    The results of this investigation showed that Jobelyn® improved neurological deficits induced by bilateral common carotid artery occlusion via inhibition of oxidative stress, neuroinflammation and neurodegeneration. These findings further support the eth-nomedicinal application of Jobelynas a therapeutic agent for the management of patients with ischemic stroke

    Stroke attack has become very rampant and it has no age barrier. If it does not result into instant death, it could turn the victim into a vegetable for the rest of his life with the quality of life reduced to almost zero. In some instances, it may give some warning signals but in many other cases, no warning will be given.

    A stroke causes a loss of function due to an interruption of blood flow to the brain. Those who suffer a stroke usually experience a number of symptoms, which may include sudden numbness or weakness of the face, arms, or legs—especially on one side of the body; confusion; trouble speaking; loss of sight; severe headaches; and loss of balance. Risk factors include hypertension, high cholesterol, obesity, advanced age, gender, and race.

    Stroke affects more than 800,000 people each year and ranks among the five leading causes of death and a leading cause of adult disability in the world. Although a stroke may not be entirely preventable, familiarity with the symptoms of a stroke can prompt you to get help faster, which can make a difference in recovery. Use the acronym FAST to remember the warning signs of a stroke:

    F – FACE. Ask the person to smile. Does the face appear crooked or drooping?

    A – ARMS. Ask the person to raise both arms. Does one arm drift downward?

    S – SPEECH. Ask the person to repeat a simple sentence. Are the words slurred?

    T – TIME. Call your doctor immediately if you observe any of these symptoms.

    It is important for people to understand stroke warning signs and get to a hospital FAST in case they are eligible to receive the appropriate treatment. Time is an important factor associated with determining whether a patient can receive it or not.”

    A scientist once said that oxidative stress may be at the root of some strokes, as the body may be unable to neutralise cell-damaging free radicals, which can lead to inflammation and vascular damage.

    How might antioxidant-rich foods reduce this stroke risk? According to the scientist, vitamins C and E, carotenoids, flavonoids, and other such compounds scavenge free radicals, thereby inhibiting oxidative stress. “Antioxidants, especially flavonoids, may also help improve endothelial function and reduce blood clotting, blood pressure, and inflammation.

     

    How stroke can be prevented

     

    Eating a healthy, antioxidant rich diet is associated other healthy behaviours. People who tend to eat healthier tend to also have healthier lifestyles as a whole, it is also noteworthy that the diet had an independent beneficial effect on stroke incidence.”

    The most congruous finding of epidemiologic studies is the lower risk of stroke among individuals with frequent consumption of fruit and vegetables. Eating a diet high in antioxidants may protect against ischemic stroke, an Italian cohort study showed.

    Antioxidants come from a variety of food sources, including fruits, vegetables, coffee, chocolate, red wine, whole grain cereals, and nuts, and diets high in antioxidants have been associated with reduced inflammation and increased circulating antioxidants.

    One of the newest, and yet oldest, treatments for stroke prevention is the dietary intake of plant compounds called flavonoids. Flavonoids are antioxidant compounds that are characterised by their polyphenolic chemical structure. Flavonoids are responsible for primary anti-oxidative effects by attracting oxygen free radicals before these free radicals can cause cellular damage.

    Over 4,000 flavonoids have been discovered, and they are found in fruit, vegetables, seeds, nuts, flowers, and bark. The best sources of flavonoids in human consumables are red wine, tea, onions, and the ubiquitous agent of health care: APPLES! Flavonoids have also been found to aid in vascular smooth muscle relaxation, which can reduce blood pressure, and thereby reduce the risk of stroke.

     

    Use of Jobelyn for treating and preventing stroke

     

    Jobelyn is a herbal product derived from Sorghum bicolour. For several centuries, the people of South-Western part of Nigeria have been using this plant in its raw form to treat and cure many diseases including stroke. The impression that I was given that this particular remedy is a cure-all for diseases like stroke, hypertension, diabetes,  arthritis and HIV. Parkinson’s  disease and sickle-cell anemia seemed illogical to me and in an attempt to find out the truth or otherwise, I have set out to carry out scientific investigations over the past 20 years. Our initial focus on the remedy as a blood boosting agent was successful and two publications  in the African Journal of Biotechnology in September 2003 confirmed that Jobelyn derived from Sorghum bicolor has the potential to be a substitute for blood transfusion except in emergency situation.  This does not give a clue to the cure-all claim of the product until we became aware of the Antioxidant properties of the product. Several studies in the US and Germany confirmed that Jobelyn is one of the most powerful antioxidants in the world.

    A synthetic antioxidant may have the ability to reduce the brain damage following a stroke by more than 40 percent — even if it’s taken hours after the stroke happens.

    A new study shows the antioxidant, known as AEOL 10150, neutralised hazardous free radicals and prevented cell death in a mouse model of stroke. Researchers say the antioxidant is designed to mimic a natural antioxidant, but it works against a wider range of free radicals and also lasts longer in the body.

    Naturally occurring antioxidants, such as vitamins C and E, are thought to reduce cell damage within the body by countering the potentially dangerous effects of free radicals produced when the body processes oxygen. Antioxidants are thought to be a promising treatment for strokes because they can be given after a stroke occurs to help reduce cell damage.

    Strokes occur when blood flow to the brain is blocked or a blood vessel within the brain ruptures. Brain cells eventually die as they become starved of oxygen, causing paralysis and loss of function. Cell damage can continue hours after a stroke.

    Having realised the potency of Jobelyn as a powerful antioxidant, we have tried it for the treatment of many diseases including stroke. For stroke that happens within 24 hours, Jobelyn take six capsules, four times daily at intervals of six hours and accompanied with daily water intake of at least three to four litres would reverse the damaging effects of the stroke within a period of two to four  weeks. For stroke that had taken long, the treatment that we have successfully adopted is four capsules of Jobelyn, three times daily, also with at least three to four litres of water daily. In this case, reversal or near-complete reversal would be possible within a period of four  to six months.

    It is, however, more advantageous to use Jobelyn to prevent stroke and many other diseases by taking a daily dose of two capsules, twice daily. The old adage that prevention is better than cure applies in this case.

    There are other aspects of health where Jobelyn has been tried. We have devised a formula for the successful treatment of Arthritis. We recommend that patients take three capsules of Jobelyn, three times daily, with three bottles of water (1.5 litre size) and in three months, the problem should be resolved. We even offer money back guarantee if  the result is not achieved. This formula could also be tried for diabetes.

     Conclusion

     

    In concluding this piece, it is necessary to emphasise that a healthy diet, which includes regular consumption of fruits and vegetables would prevent many serious diseases but we need to state that a powerful antioxidant like Jobelyn, concentrated in capsules could as well prevent you from diseases and taken at a higher dosage could also reverse diseases and help you to maintain your wellness.

     

    • For further details on the use of Jobelyn for the treatment and prevention of stroke, please send text message to whatsapp at +234 8189576022 or send e-mail to okubena@gmail.com

  • ‘Nigerian scientists confirm power of Jobelyn’

    The Chief Executive Officer of Health Forever Product Limited, Ikeja, Lagos, producer of the natural dietary supplement, Jobelyn, Otunba Olajuwon Okubena answers the question.

    Arthritis is a group of conditions involving damage to the joints of the body. Arthritis is the leading cause of disability in people older than fifty-five years.

    There are different forms of arthritis; each having different causes. The most common form of arthritis, osteoarthritis (degenerative joint disease) is a result of trauma to the joint, infection of the joint, or age. Emerging evidence suggests that abnormal anatomy might contribute to the early development of osteoarthritis.  Other arthritis are rheumatoid arthritis and psoriatic arthritis, autoimmune diseases in which the body attacks itself.

    Medical doctors believe there is no cure for arthritis, and so they prescribe treatments that will lessen the pains and discomfort arising from it. Tylenol, aspirin, and ibuprofen are but a few of the non-prescription drugs that the doctor may recommend. Others may include cyclo-oxygenase-2 (COX-2) inhibitors, steroids, and anti-biologics. Surgery is an option is some instances. But what physicians recommend most are effective pain-lessening treatments for arthritis.

    Scientists from Neuropharmacology Unit, Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, led by Dr Solomon Mukoro in a recent animal model in vivo study, postulated that Jobelyn has the potential to treat Rheumatoid Arthritis in human.

    In a recent article published in the journal “Biomedicine & Pharmacotherapy”  (https://doi.org/10.1016/j.biopha.2017.12.098),  it was reported that Rheumatoid Arthritis (RA) is a chronic inflammatory disease that affects the physical and psycho-social well being of the patients and a major cause of work disability. Current drugs for its treatment only provide palliative effect, as cure for the disease still remains elusive. Jobelyn, a potent anti-oxidant and anti-inflammatory dietary supplement obtained from Sorghum bicolor, has been claimed to relieve arthritic pain.

    Thus, this study was designed to evaluate its effect on inflammatory and biochemical changes as well as neurobehavioural deficits associated with complete Freund-adjuvant (CFA)-induced arthritis in mice. The effect of Jobelyn on inflammatory oedema, neuro-behavioural deficits, levels of bio-markers of oxidative stress and inflammatory cytokines (tumor necrosis factor-alpha and interleukin-6) was evaluated in male Swiss mice.

    Oral administration of Jobelyn reduced inflammatory paw volume and reversed sensori motor deficits induced by CFA. Jobelyn also reduced pain episodes, anxiety and depressive-like symptoms in CFA-mice. The increased level of oxidative stress in the joint and brain tissues of CFA mice was reduced by Jobelyn. It also decreased tumor necrosis factor-alpha and interleukin-6 levels induced by CFA in the joint tissue of mice.

    According to the scientists these findings suggest that Jobelyn attenuates inflammatory responses induced by CFA in mice via inhibition of oxidative stress and release of inflammatory cytokines. The ability of Jobelyn to attenuate CFA-induced nociception, sensori motor deficits and depressive-like symptom suggests it might improve the quality of life of patients with arthritic conditions.

    The full research paper could be accessed at:https://www.afritrado medic.com/pdf/Jobelyn% C2%AE%20attenuates%20 inflammatory%20 responses%20Freund-adjuvant-induced%20 arthritis%20 in%20mice.pdf

    In an earlier study published in https://doi.org/10.1016/j.biopha.2017.12.098 (De Gruyter), the authors in article titled Jobelyn exhibited anti-inflammatory, antioxidant, and membrane-stabilizing activities in experimental models, the authors stated that Jobelyn is an African sorghum-based food supplement claimed to be efficacious for the treatment of rheumatoid arthritis (RA).

    Although in vitro studies confirmed its anti-inflammatory property, no study had shown the effect of Jobelyn using in vivo animal models of inflammation. Thus, its effects on acute and chronic inflammation in rats were evaluated in this study. Its effect on rat red blood cell (RBC) lysis was also assessed.

    The results of the experiment confirmed that given orally, Jobelyn produced a significant inhibition of acute inflammation induced by carrageenan in rats. It reduced the volume and number of leukocytes in inflammatory fluid in the granuloma air pouch model of chronic inflammation. It further decreased the levels of MDA in the fluid suggesting antioxidant property. Jobelyn elevated the concentrations of GSH in inflammatory exudates, indicating free radical scavenging activity. It also significantly inhibited RBC lysis caused by hypotonic medium, suggesting membrane-stabilizing property.

    The authors concluded that Jobelyn has in vivo anti-inflammatory activity, which may be related to its antioxidant and membrane stabilising properties, supporting its use for the treatment of arthritic disorder.

    The full length paper could be accessed at:

    https://www.researchgate.net/publication/277409295_ Jobelyn_exhibited_anti-inflammatory_ antioxidant_and_membrane-stabilizing_ activities_in_experi-mental_ models.

    Having now proven the potential of Jobelyn to cure rheumatoid arthritis in animal model, the scientists have offered the product for human clinical trials, which when successfully done would place the product on the world map as the first of its kind in the natural product category to provide the much needed medication to help the millions of sufferers from this disease. Human and animal trials published in reputable journals have confirmed the safety of the product.

    An old adage says that prevention is better than cure. Medical doctors believe there is no cure for arthritis, and so they prescribe treatments that will lessen the pain and discomfort of arthritis.

    Natural medicine practitioners believe there is no disease without cure, arthritis not exempted. There abound several testimonies of patients, who have used methods other than the strict orthodox to cure themselves of arthritis. A woman cured herself of arthritis following the following steps:

    “I got rid of my arthritis by radically changing my diet. I tell people with arthritis that if you want to get rid of it, you have to give up everything enjoyable except sex. I spent three weeks on the diet. I bought an electric juice extractor and for the first three days the only food I consumed was freshly extracted fruit juice and vegetable juice. I drank the juice five or six times a day, a couple of glasses at a time, or whatever I felt comfortable with. I also drank peppermint tea and rain water.

    “You must drink the juice as soon as you extract it – don’t keep it in the fridge for later, and don’t use juice bought from a supermarket. After three days you continue with the juice every day, but additionally you start eating raw fruit, raw vegetables and raw nuts in quantities you’re comfortable with – graze throughout the day rather than sit down to three meals.

    “Herb tea and rain water are the only drinks allowed – I drank Peppermint tea and still do. The emphasis is on fresh raw food and juices – nothing is to be cooked. You can’t add anything to the food either, such as salt, sugar, sauce, but you can use herbs to flavour the raw vegetables. Alcohol and caffeine are strictly forbidden. In fact, everything is strictly forbidden except fresh fruit juice and vegetable juice, whole fresh raw fruit and vegetable, raw nuts, herb tea and rain water. The distilled water you can buy in supermarkets would probably be okay too, but town water that’s chlorinated is definitely out,”she said.

    “The purpose of this diet is to flush the toxins out of your body, particularly uric acid. Uric acid, as doctors know, is a bad inflammatory agent that deposits itself as crystals in the joints and in places of injury in the body. It helps to cause the pain, inflammation and swelling associated with arthritis.

    Doctors prescribe drugs to combat the effects of uric acid, but a far more effective way is to flush it out of your system so that it can’t cause problems. Uric acid is one of the many toxic by-products produced from food during the digestive process. On the typical western diet there is such an over-abundance of these toxins produced within the body that the organs can’t cope with the excessive workload, and the toxins build up to the point where they can start causing problems.

    The idea is to change over to an easily digestible diet that produces a minimum amount of toxic by-products. The eliminative organs of the body can easily cope with the greatly reduced workload, and also clear out the backlog of accumulated toxins.

    “As the toxins were cleared from my body my pain and swelling reduced progressively until after about two weeks I was about 80 per cent clear of pain and I stopped the anti-inflammatory drugs.

    “After three weeks I was totally clear of all symptoms of arthritis – no pain, no swelling – nothing. As a long term maintenance programme you can go on to a 75/25 diet, i.e. each meal must contain at least, 75 per cent good foods and no more than 25 per cent bad foods. Good foods are all those included in the three week diet. Bad foods are all other foods.

    “If you really want to maintain optimal health, eat raw fruit, raw vegetables, and raw nuts as your only food for the rest of your life. If you are to prevent arthritis from destroying your life you must refrain from processed foods and other acid forming foods. Normally, a healthy diet should be 70 per cent alkaline and 30 per cent  acidic.  Alkaline foods are typically foods which are still in their natural state (raw and fresh). And acidic foods are typically foods which have been altered through processing, frying, and high-fat cooking.

    “Therefore, instead of eating acidic foods (cooked and processed), you should be eating mostly raw, fresh vegetables and fruits. They are rich in antioxidants which neutralize free radicals that are responsible for inflammation, arthritis and pains. Also, reducing the consumption of meat can also be helpful against arthritis. By eating less meat and more fresh fruits and vegetables, one would be allowing your body to receive more nutrients and keep your acidic levels low. The  result of your new diet could change the pain and inflammation affecting your arthritic joints.

    Some years ago, a middle aged woman was escorted to my office by a friend to seek solution for her arthritis problem. It was a big problem for her to even sit down on the chair. She wasted no time in narrating her story. “My grandmother died of arthritis complications, my mother is on wheel chair at home, and having lost the ability to move about and here I am at the verge of completely breaking down for the same dreadful arthritis. We have exhausted all prescribed medications. Is there any hope?”  I recommended that she should take three capsules of Jobelyn, three times daily and drink lots of water, minimum of 3 to five litres daily. “Is that all?, she said. I had to offer her a refund for the purchase of this product if after one month of treatment; her condition did not improve considerably.  Her return before the end of the month was to give testimony and introduce two other friends going through the pains and agony of arthritis.

    In my excitement, I informed my friend, Dr. David Abia-Okon (a surgeon) of my new discovery for Jobelyn. Though he is a fanatical believer in Jobelyn but he confines his use of Jobelyn to the treatment of Anaemia, Sickle-Cell Anaemia and Stroke, he refused to embrace the idea of Jobelyn being capable of tackling the problem of Arthritis. The only way to convince him was through scientific evidence. In spite of the test-tube experiments

  • Jobelyn ‘can assist cancer cases’

    Cancer has remained a dreaded disease to humanity. The scientific and technological development across the world does not alter this statement. Even in the United States (US) where medical science has reached its peak, the position remains the same. When Mr. Nixon was president of the US, it was decreed that the cure for Cancer must be found within 10 years or so. This was several decades ago, but there is no light at the end of the tunnel yet. The solution to the problem of Cancer is buried in nature and until humanity bows to nature, human suffering as a result of cancer would continue unabated.

    By profession, I am a Chartered Accountant and a Management Consultant, who was led by nature to discover a clue that would eventually make a big impact in the quest to find a solution to the problem of cancer. After a distinguished career in accounting and management consultancy, nature shifted my focus to investigating how a simple folk medicine may solve most of human health problems.

    An attempt on my life in 1993 was the major turning point in my life. I was introduced to a herbal practitioner, who was using a single herb to treat all his patients. I was later to discover that this herb was a special Sorghum bicolor leaf sheath, which had been in use as folk medicine by the natives of Southwestern Nigeria for centuries, to cure diseases of diverse origins, including cancer, diabetes, arthritis, hypertension, stroke, heart diseases, anemia, sickle cell anemia and neurological disorders. My two-year apprenticeship under this herbalist convinced me that it was indeed, a truth that he was using the single herb to cure every disease. I was a witness to the cure of a Teaching Hospital professor, who had a terminal case of Leukemia and this happened within a record time of 3 months.

    I decided to embark on an adventure to provide a credible evidence to substantiate the awesome power of this herb and this project started in 1996. I am satisfied that the effort has so far been fruitful.  My initial task was to transform the herbal concoction from a water extract to a capsule form. I consider this would be more appealing to users including medical scientists.

    The first publication in the Nigerian popular newspaper, The Guardian, created the first awareness and this was before it was packaged as a commercial product.

    In 1998, the product was offered free for Leukemia trial on the internet and someone from the US accepted the offer and the summary of the outcome is as follows:

    An American, whose wife is an associate professor in the Department of Occupational Therapy, Boston University, Massachusetts, US.

    He had Acute Myeloid Leukemia, refractory type M-O. He received three courses of chemotherapy between October and January 1996 -1997.  Two weeks after the last chemotherapy, his leukemia relapsed.

    He subsequently underwent a bone marrow transplant, but the leukemia relapsed later.  He went for another protocol in which he received lymphocyte infusion (helper – T cells) followed by three weeks of interleukin-2 injections.  In spite of all these, his blasts continued to increase and the haematocrit kept going down.  He was transfused with two pints of whole blood every other day.  He also received multiple platelet transfusions.  His case was dismissed by his doctors at Dana Farber Cancer Centre (one of the best two cancer centres in the world) as irredeemable.  He was given two days to live after discharge from hospital.

    His wife placed an order for Jubi capsules (Now Jobelyn) through the internet.  Though the patient is now deceased, his condition while on this therapy  could best be summarised in the spouse’s  own words “The Jubi Formula definitely stabilised his haematocrit for as long as he took it and it may have prolonged his life a few weeks.  Having been able to keep him alive for a month after they thought he was going to die was worth it.

    Another testimony was from the father of a 26-year–old leukemia patient, whose ailment had defied chemotherapy and who was on the verge of receiving a bone marrow transplant. He came to Nigeria from America to procure Jobelyn for his son and returned four to five month afterwards to say that his son had been discharged from hospital as result of complete remission.

    Up to this stage, we did not have any scientific evidence to back up a claim that Jobelyn was useful for the treatment of Cancer, but the work we have done in the past 15 years had provided abundant evidence. It was climaxed by the discovery of a compound which activated the NK Cells and  showed potential in cancer immuno-surveillance.

    After about 80 years of vigorous efforts to find a cure for Cancer, the treatments available are chemotheraphy, surgery and radiotheraphy. Everybody is aware of the dangerous side effects of these therapies. Patients, who survive five years after the start of chemotherapy are regarded as having been cured. Most of the patients do not survive for this length of time.

    In recent times, serious attention is being given to the new science called immuno-therapy. While I was writing this article, I came across an article based on a recent CNN broadcast on the recent developments in this field of science.

    “Cancer immuno-therapy really refers to treatments that use your own immune system to recognise, control and hopefully ultimately cure cancers,” said Jill O’Donnell-Tormey, Chief Executive Officer (CEO) of the Cancer Research Institute, during the conference in New York last month.

    “Many people for many years didn’t think the immune system was really going to have a role in any treatment for cancer, but I think the entire medical community (and) oncologists now agree that immunotherapy is here to stay,” she said.

    The specific sector of the immune system that is responsible for the immuno-therapy function is known as the NK (Natural Killer) Cells.

    The big pharmaceutical companies are now in a rat race to produce drugs or technology that would activate the NK Cells for cancer immuno-therapy and they are facing formidable difficulties. The issue of side effects is enormous and the cost of the finished product would undoubtedly be beyond the reach of the average citizens.

    Medical scientists believe that nature is primitive and that they could ignore nature to find solutions to many problems including health issues. They have not been able to produce a trouble free solution. The approach to solve the problem of cancer with chemotherapy is a complete failure and hence the recent realisation that the immune cells offer the best approach to solving cancer problems.

    But how do you assist the immune cells to achieve this objective? There are several ways that scientists have been exploring. One is by inventing vaccines and the other way is by extraction of the T Cells and manipulating them before re-introducing them to the patients to activate the NK Cells for them to  destroy cancer cells. These unnatural ways have been creating problems and side effects.

    The natives of Southwestern Nigeria claimed they have been treating cancer for decades, using Tradition Herbal preparations but they have either been scorned or ignored because they did not have scientific evidence to back up their claims.

    We have spent the last 20 years carrying out studies and have reached a milestone that could not be ignored in our quest to prove that an African Traditional Medicinal product has some measure of scientific evidence  to support its claim for treatment of cancer.

    In a research carried out at Natural Immune System (NIS) Laboratory, Oregon, in the US and published in the Journal of Medicinal Food with the title: “West African Sorghum Bicolor Leaf Sheaths Have Anti-Inflammatory and Immune-Modulating Properties In Vitro”, it was reported that both aqueous and non aqueous compounds in Jobelyn contribute to anti-inflammatory effects, combined with multiple effects on immune cell activation status. These observations may help suggest mechanisms of action that contribute to the traditional use of sorghum-based products, beverages, and extracts for immune support.

    The latest research carried out by scientists at Lagos State University Teaching Hospital (LASUTH), was published in the Journal of Cancer Research Therapy under the title: “Newly isolated compounds from West African Sorghum bicolor leaf sheaths Jobelyn show potential in cancer immuno-surveillance”. It was concluded that “evidence of innate effector cells activation by ethanolic extracts of Jobelyn® suggests that this variety of Sorghum may be able to mediate direct cell cytotoxicity supporting the control and clearance of a number of tumour cells”.

    Almost all the leading big pharmaceutical companies are investing millions of dollars in immuno-therapy to provide the solution to the problem of cancer, but they have been meeting obstacles because they are ignoring nature in their approach. Vaccines and synthetic agents are repulsive to the sensitive nature of immune system. The solution could only come from organic molecules derived from natural plant sources. Jobelyn has produced the molecule that has demonstrated its potential in cancer immune surveillance. This is no doubt an in vitro experiment and the product will soon be subjected to human clinical trials for Breast Cancer at a Nigeria Teaching Hospital.  Jobelyn, a natural product derived from a unique variety of Sorghum bicolor, has been in use for centuries by Africans for the treatment of cancer and many other ailments.

    Cancer is a complex disease and the current approach to treatment is multi-dimensional. One of the important aspects to Cancer treatment is appropriate food and nutrition. Jobelyn is a perfect example of food and medicine that play an important role in the treatment of cancer.

    Jobelyn’s nutritional contents were assessed by GMP Laboratories of America, Inc., CA, US. SBLS was proven to be a good source of minerals like calcium (35.2 per cent RDA), magnesium (59.03 per cent RDA), sodium (95.83 per cent RDA), selenium (28.0 per cent RDA), Zinc (13.62 per cent RDA) and copper (127.77 per cent RDA). RDA means Recommended Daily Allowance and it is set by Food and Drugs Authority (FDA) in the US.

    More interestingly, it was observed that 100g of this extract provides around 285 per cent of the daily recommended levels of iron.

    Jobelyn contains large amounts of iron and as such it is used in the treatment of anemia. However, most of the excess iron from Jobelyn is chelated by the polyphenols in the sorghum extract and as a result the excess iron is not presented to the body. Such observation suggests that the use of Jobelyn can help improve haematocric (blood level) and quality of life in cancer patients as well as reduce several micronutrients deficiencies, which are common in those patients.

     

    Vitamin Contents in Jobelyn

     

    Jobelyn also contains substantial amounts of vital vitamin B12.

    It is a water soluble vitamin that acts as a cofactor in the conversion of homocysteine to methionine and methyl tetrahydrofolate to tetrahydrofolate.

    Polyglutamate is further added to tetrahydrofolate to prevent the diffusion of folates out of the cell. Folates are essential for the building blocks of DNA in rapidly regenerating organs like the production of blood while excess homocysteine is known to cause endothelial damage and therefore, cardiovascular disease.  It is well documented that the body cannot produce B12 and that it can only be sourced from animal foods or in the form of B12 vitamin supplement.

    Deficiency usually results in anemia, impaired brain function, and symptoms of mental disorder. The only good food sources of B12 are primarily animal foods like meat, fish and eggs producing 2.8 µg/100 1.95 µg/100; 4.15 µg/100 of B12, respectively. Interestingly, Jobelyn is a good source of B12 producing 0.83 µg/100 g. This is the first time a plant product has been reported to contain significant amounts (34 per cent) of vitamin B12. Vitamin B12 could potentially be a useful antioxidant as it directs reaction with reactive oxygen species and through glutathione sparing effect, can modify signalling molecules to decrease oxidative stress and increase total antioxidant capacity

     

    Fatty Acids Contents in Jobelyn

    Jobelyn provides an impressive 1:3 ratio of Omega-3 to that of Omega-6 and as population studies indicate, our diet should contain no more than three parts of Omega-6 to one part of Omega-3, which is ideal for the heart’s health. Omega-6 fats have pro-inflammatory effects while omega-3 fats have anti-inflammatory effects. The ratio of 3:1 will reduce the chronic inflammation that most people recognise as the root cause of many chronic diseases, including diabetes and cancer.  Omega-3 fatty acids play important role in every cell in the body. Omega-3 makes up cell membrane and helps in maintaining membrane fluidity, keeps the nervous system functioning by up-regulating brain derived neurotropic factor (BDNF) and modulating neurotransamitters re-uptake, degradation, synthesis and anti-apoptotic effects once it gets converted into fatty acids eicosapentaenoic acid (EPA) and later docosahexaenoic acid (DHA).

    However, Omega-6 inhibits the conversion of Omega-3 into DHA and EPA, therefore, the adequate ratio of 1:2 or 1:3 is usually required to allow conversion of adequate amounts of Omega-3. The Omega balance is critical as Omega-3 and Omega-6 compete for absorption into the cells, and an excess of dietary Omega-6 will result in too few of Omega-6 being incorporated into cell membranes, from where they exert their essential effects

    In some developed countries, alternative holistic systems have been established after identifying the limitation of the orthodox system. There are centres in Tijuana (Mexico), Israel, Germany and other countries where cancer problem is being addressed with holistic system. Patients in search of the holistic solution travel to these places from the US in spite of their highly developed medical system. We are proposing to establish an integrative system in Nigeria where complete wellness would be the target. It will combine the best in orthodox with natural and traditional systems to provide reliable solution for cancer patients in Nigeria. This will saves a lot of foreign exchange from medical tourism by Nigerians to foreign countries like India, Germany, Israel and other countries in search of solution to cancer problems. We hope that that when this system is fully developed, people from developed countries would be attracted to Nigeria for a better solution to their cancer problems.

  • Herbal Product of Year 2013…Jobelyn (3)

    Herbal Product of Year 2013…Jobelyn (3)

    Clinical Efficacy of a West African Sorghum bicolor-Based Traditional Herbal Preparation Jobelyn Shows Increase Hemoglobin and CD4 +T-Lymphocyte Counts in HIV + Patients

    This column concludes the three-part series of HERBAL PRODUCT OF YEAR 2013… JOBELYN. It answers a major question asked by many readers who were surprised to read in the first two parts that a cure for HIV may, indeed, exist, let alone in a herbal formula. This column is a feature of the publication, in a peer reviewed respectable journal, of the research of Jobelyn in HIV therapy.

     

    Abstract

    Objectives: The purpose of this study was to evaluate a traditional herbal preparation Jobelyn® for its effects on anemia and CD4+ T cell counts in HIV+ patients in Nigeria.

    Design: An open-label pilot study involving 10 confirmed HIV+ patients who were not receiving antiretroviral therapy (ARVT) was performed, where the patients consumed Jobelyn® for eight weeks, at a dose of 500mg twice daily. The pilot study was followed by a controlled trial involving 51 patients, all confirmed HIV+, where the patients with CD4+ T cell counts below 350 cells/uL were receiving ARVT. The eight patients with baseline CD4+ T cell counts above 350 cells/uL received Jobelyn®. The remaining patients who all received ARVT were randomised to ARVT alone versus ARVT + Jobelyn® for 12 weeks.

     

    Introduction

    There is a worldwide recognition of the vital roles of the need for integrated interventions, including herbal medicines, as a necessary tool in global health-care, particularly in third world countries with poor access to pharmaceutical therapeutic strategies that are widely used in industrialised countries. With a focus on the human immunodeficiency virus (HIV), the World Health Organisation encourages the use of available resources for primary health care (PHC). It further recommends that governments give high priority to the use and incorporation of proven traditional remedies into a comprehensive health care. Despite the well-developed pharmaceutical industry in industrialised countries, the standard-of-care in most third-world countries place emphasis on the use of local resources such as traditionally used medicinal plants.

    Jobelyn® is a natural product developed from tropical plants found within the Nigerian flora. Toxicological evaluation in laboratory animals has shown a satisfactory safety and side effects profile. It has been found to induce rapid and marked improvement in anemia. The suggested mechanism of action was an immune-boosting effect, which is interesting in light of the presence of anti-viral peptides in some parts of the Sorghum plant, as well as unique polyphenol compounds identified in Jobelyn®. Evidence for in-vitro for many biological properties of Jobelyn® was recently published. The data includes immune modulation, activation of Natural Killer cells involved in antiviral immune defense actions, and up-regulating of the production of anti-viral chemokines.

    Jobelyn®’s effects on anaemia lead to the speculation whether the effect on red blood cell production as well as production of other cell types may be positively affected. Limited use in uncontrolled trials in antiretroviral-naive HIV-infected subjects as well as patients on Highly Active Anti-Retroviral Therapy (HAART) has suggested some improvement in several haematological parameters and quality of life. HAART uses a combination of reverse transcriptase inhibitors and protease inhibitors and is the current standard drug treatment of HIV/AIDS. Appropriate and consistent use of HAART can help reduce viral load and allow for some immune system reconstitution, including an increase in CD4+ T cell counts. However, even with heavy subsidy, HAART is neither accessible nor affordable to a majority of people living with HIV/AIDS in third-world countries. Use of HAART is also limited by potential toxicity and side effects, as well as development of resistant strains of HIV. Only patients whose biological profiles fit the eligibility criteria are typically treated with HAART. These limitations underline the need for continued search for viable alternatives or adjuncts to HAART.

    Increasing use of Jobelyn® by many HIV+ patients and people with anaemia justify further evaluation of its efficacy for support of production of lymphocytes and red blood cells in people with bone marrow suppression. This study was, therefore, designed to address these questions. Two clinical pilot studies were performed on patients with HIV in Lagos, Nigeria. An initial pilot study involved 10 HIV+ patients who also suffered from anemic conditions. A subsequent controlled study continued to evaluate the effects of CD4+ T cell counts in HIV+ patients, of which some also received anti-retroviral treatment. The controlled study aimed at evaluating the role (if any) of Jobelyn® in the management of HIV in the presence or absence of HAART.

     

    Methods

    Nutritional supplement:

    The consumable nutritional supplement Jobelyn™ was grown, harvested, and manufactured by Health Forever Products, Ikeja, Lagos, Nigeria, using seed stock from a recently domesticated variant of West African Sorghum bicolor. One lot was used for the open-label pilot study, and a second lot was used for the controlled trial. Both lots had similar chemistry profiles showing a very high content of polyphenols, particularly apigeninidin, which was present at approximately 4 per cent of the dry weight of the botanical material (Table 1). This level is consistent with other lots tested for immune modulating activities.

     

    Trial 1:

    Ten patients (four men and six women, age range 23-49 years) with confirmed HIV+, a reduced number of CD4+ T lymphocytes, who did not qualify for anti-retroviral therapy (ARVT), and who consumed Jobelyn®, were followed through the Police Hospital in Lagos, Nigeria for eight weeks. Potential study participants were regular patients of Dr. N. U. Eguae, and invited to participate by use of written informed consent. The number of CD4+ T lymphocytes and the haemoglobin level was evaluated at baseline, four and eight weeks.

     

    Trial 2:

    Based on this pilot data, a controlled trial was performed at the Clinical Research Division of the Military Hospital, Ikoyi, Lagos, Nigeria. 51 patients (28 men and 23 women, age range 18-67 years) were enrolled in the study upon written informed consent, as approved by the Ikoyi Military Hospital Institutional Review Board. Potential study participants were regular patients of Dr. Ayuba, and invited to participate, by use of written informed consent. All study participants who at the time of screening had CD4+ T cell counts below 350 cells/microlitre were treated with anti-retroviral treatment (ARVT), which consisted of Nevirapine (200 mg), Lamivudine (150 mg) and Stavudine (40 mg) twice daily. All 51 patients who participated in this clinical trial were monitored for CD4+ T cell counts at baseline, six, and 12 weeks. Eight patients who at the time of screening had a CD4+ T cell count at 350 or higher were ineligible for ARVT, and received Jobelyn® for the same duration of 12 weeks. The remaining 43 patients were randomised into two groups, where one group of 16 people were only treated with ARVT, and the other group of 27 people were treated with ARVT and also consumed Jobelyn® daily for 12 weeks. There was no significant difference in the baseline CD4+ T cell counts between these two groups. Data were analysed using ‘within-subject’ analysis using the paired two-tailed t-test, as well as ‘between-groups’ analysis, using the unpaired two-tailed t-test.

     

    Results

    Trial 1: A statistically significant increase in CD4+ T lymphocytes (p<0.01) and hemoglobin (p<0.001) was observed within four weeks, using the paired 2-tailed t-test. Among the 10 participants, everyone showed an improvement in both CD4+ T cell count and in hemoglobin levels (Table 2). All 10 patients had haemoglobin levels below normal for their gender at baseline. All of them showed an improvement in hemoglobin levels. After eight weeks of consuming Jobelyn®, all 10 patients had haemoglobin levels near the lower normal range.

    Trial 2: Among the 51 patients participating in this controlled trial, 43 patients had baseline CD4+ T cell counts at or below 350 cells/uL, and received ARVT.

    As expected, people on ARVT showed a statistically significant improvement in their CD4+ T cell counts across the 12-week study period (n=16, p<0.01) (Figure 1). However, patients receiving ARVT + Jobelyn® showed a more robust improvement, which reached a high level of statistical significance compared to baseline already at six weeks (n=27, p<0.001), and remained highly significant at 12 weeks (p<0.001). (Figure 1). Analysis comparing the two groups showed that the CD4+ T cell counts in the group receiving ARVT+Jobelyn® was significantly higher than the group receiving ARVT alone, both at six and 12 weeks (p<0.001).

    Within the study population of 51 people, only three patients had lower CD4+ T cell counts after the 12 weeks study than at study baseline; all three patients received ARVT, and two of them also consumed Jobelyn®. These three people experienced concurrent infections (tuberculosis, pneumonia) during the time. Patients’ appetite and weight increased and there was improvement in their general well-being. The maculo-papular skin rash of three of the patients who had Herpes zoster remitted.

    The third group of patients, namely those eight people who received Jobelyn® only, since they were not eligible for ARVT due to a higher CD4+ T cell count at baseline, also showed an improvement during the weeks of Jobelyn® consumption (Figure 1). This improvement was statistically significant from baseline after 12 weeks (p<0.01).

     

    Discussion

    The core result presented here is the improvement in CD4+ T cell numbers over time in the two groups that consumed Jobelyn® when compared to the group treated with conventional antiretroviral treatment only. An additional observation from the initial pilot study is the improved haemoglobin levels seen in HIV+ patients consuming Jobelyn for eight weeks.

    The parallel increase in haemoglobin and CD4+ T cell counts seen in the pilot study suggest that consumption of Jobelyn® may support several aspects of bone marrow function. The data from the controlled study involving 51 people suggests support of T cell production. The primary mechanism likely includes support of bone marrow function since anemic conditions were also reduced, possibly combined with secondary mechanisms of enhanced immune defense against viral infection. In addition, an anti-viral effect may be suggested, based on the observations that Jobelyn® provides several aspects of anti-viral immune support in vitro, which includes activation of Natural Killer cells and production of chemokines MIP-1a, MIP-1b, and RANTES.11

    Future clinical studies need to address whether Jobelyn® has similar effects in populations with different demographics, diet, and lifestyle, as well as different prevalence of concomitant infectious diseases. Also, the suggested mechanisms of action may be further evaluated through testing of serum cytokine/chemokine profiles, including growth factors with known effects on bone marrow function, and anti-viral chemokines. These effects by Jobelyn® may suggest a role for its use in broader health management, and not limited to HIV or HIV-associated anemia alone. Clinical trials are currently ongoing to examine the effects of Jobelyn® on anaemia in non-HIV+ study populations. Given the significant effects seen over a relatively short study period in a West African population, consideration should be given to expand its use in other countries with different health challenges, to help augment health improvements in acute and chronic viral illnesses.

     

    Acknowledgements

    The two studies presented here were conducted at the Police Hospital and the Military Hospital, both in Lagos, Nigeria. The data analysis was performed at NIS Labs, Oregon, USA. The studies were sponsored by Health Forever International, Inc.

     

    Disclosure statement

    GS Jensen, KF Benson, and R Blake are associated with NIS Labs, and Colonel GI Ayuba was employed as staff physician at the Military Hospital at the time this study was conducted. None of these people have any commercial interest in this subject matter. A and O. Okubena are directors at Health Forever International, Inc., the sponsor of this work.

    •CD4+ T cell counts are shown as cells per microliter whole blood.

    •Haemoglobin levels are shown as gram/dL.

    •ARVT: Anti-retroviral therapy.

    • JOB: Jobelyn®, which was consumed at a dose of 500mg twice daily.

    • Data analysis utilised the within-subject two-tailed paired t-test to compare each person’s changes for Week six and Week 12 to baseline values.

  • Herbal Product of Year 2013…Jobelyn (1)

    A few months ago, I received the idea that, like The Man Of The Year Award in a New Year, there ought to be a Nigerian Herbal Product of the Year. The Venture recognises untiring efforts to develop for Nigeria’s Traditional Medicine (NTM) which are respected in the trillion-dollar world market for herbs. Not only are world market herbal products well researched and clinically proven to be therapeutically effective, and safe, their production must be sustainable and their components standardised. I choose JOBELYN as the PRODUCT OF THE YEAR perhaps because, having followed its trajectory since 1994, I found it without much labour to satisfy these criteria. I have reported many of its events, and know it’s history like the back of my palm. I went over its history as recorded now by the producers, HEALTH FOREVER LIMITED, to piece together the official records which tells the JOBELYN story as follows…Between 2003 and 2013 many studies were carried out, and some of the findings were published in reputable international, peer reviewed scientific journals. Among these studies were those done at the Lagos State University Teaching Hospital (LASUTH) and the University of Ibadan (UI). That is not to mention the College of Medicine of the University of Lagos (CMUL) and the university of Benin (UNIBEN). For a Nigerian herbal product, this is a great achievement. The roll is something like this

    August 2003

    Preliminary study of United States based BDCP (Bioresources Development and Convervation Programme, suggests “direct antimalarial activity, antioxidant property and mild antimicrobial effects”.

    September 2003

    Lagos University Teaching Hospital (LUTH) found that Jobelyn “has a potential for influencing the state of anaemia in try panosome infected rats”. Although it may not destroy the try panosome, Jobelyn boosts “the capacity of the host to fight the invading parasites”. The report appeared in the African journal of Biotechnology vol 2(9) pages 312 – 316 of September 2003 and is available online the same study found that Jobelyn, then known as JUBI BLOOD FORMULA, “can increase PCV and Hb in concentrations in anaemic laboratory rabbits… the herbal preparation may be useful in the treatment of anaemia as claimed and may be a potential substitute for blood transfusion.

    AUGUST 2004

    Phytolabs GmBH & Co of Germany found polyphone antioxidative plant substances, in high concentrations in Jobelyn.

    EARLIER IN 2003

    Vivacell of Germany discovered in Jobelyn anti-inflamatory substances called CYTOKIMS which should make the product useful for inflammatory diseases for which medicine is still searching for safe pharmaceutical drugs.

    2006 STUDY

    Bruns Wick Laboratory in the United States found five chemical markers of high value in anti-inflammation therapy. These included

    (1) Epigenidin

    (2) Luteolinindin

    (3) Apigenin

    (4) Luteonin and

    (5) Naringenin

    2005 STUDY

    Studies to determine anti-inflammatory effects of Jobelyn were carried out by (1) the Pharmacology Department of Obafemi Awolowo University (OAU), Ile-Ife (2) Brunswick Laboratory, USA.

    2008 STUDY

    Four compounds in Jobelyn were tested for their ability to decrease the bodys production of Prostaglandin E2 series, which trigger inflammation pain and tissue damage such as in arthritis of asthma. These compounds effectively decreased amounts of this damaging biochemical substance and blocked the pathway (Cox2) through which Prostaglandin E2 creates and sustains inflammation.

    ANOTHER 2006 STUDY

    Carried out in Germany by the SGS INSTITUTE PRESENUS, this one evaluated the nutritional or supplement facts.

    JOBELYN 2009 STUDY

    Carried out by Brunswick Laboratory, it determined the antioxidant effects of Jobelyn. Later studies found this product has ORAC (Oxygen Radical Absorbent Capacity) thousands of times higher than Euro-American plants suggested to be among the wilds best anti-oxidant edibles.

    2009 STUDY

    This was about the cosmetic value of Jobelyn. Brunswick Laboratory checked Jobelyn’s capacity to neutralise five of the major free radical groups which damage subcutaneous fat bed of the skin as well as the collagen scaffolding, which gives structure to the skin, and elastin, which makes the skin elastic.

    The study found that Jobelyn destroys elastase, the free radical which destroys elastin, 22 times better than vitamin c, eight times better than ferrulic acid and 1.5 times better than quercidin. Against collagenese, which damages collagen, Jobelyn was reported to act 15 times better than vitamin C and 30 times better than ferrul acid.

    2012 STUDY

    Texas University identified two compounds… the first time an apigenin – apigenin condensation product would be reported found in sorghum bicolour, one of the ingredients of Jobelyn.

    ANOTHER 2012 STUDY

    Researchers at the University of Ibadan found that Jobelyn reduced symptoms of psychosis and was helpful in combating memory deficits, possible by eliminating reactive oxygen.

    This was the first in a series of such studies. Another found that Jobelyn was antipsychotic without the crippling effects of drugs traditionally used in conventional therapies.

    ANOTHER 2012 STUDY

    As the Lagos State University Teaching Hospital (LASUTH) researchers checked if the effect of the extract of soghum bicolour on the hematological parameters of patients with sickle cell aneamia.

    JOBELYN

    There was no significant rise in white blood count, and platelet count and red cell distribution, contrary to effects in rate. The researchers said that while the extract may have a significant effect in sickle cell anaemia therapy, it is not toxic to the bone marrow. There was a significant reduction in mean cell haemoglobin concentration which may suggest the extract may prevent cellular dehydration and so, may reduce the rate of sickling.

    2014 STUDY

    To begin next month in LASUTH is a random study to evaluate safety and effectiveness of Jobelyn in breast cancer therapy.

    OBSERVATION

    I found these efforts worthy of mention in a country where many people are only concerned about making money and not ploughing back some of the profit they make in Research and Development such as attitude makes a nation not inventiful but a dumping ground of the fruits of the labour of other nations. The Jobelyn story, in my view, show that Jobelyn can give Nigeria a National Herbal Product to complete in the trillion dollar world herbal market. Blood is central to life. Everyone, African or European, Asian or American has blood flowing in his or her veins in need everyday, of rejuvenation. I asked Mr. Olajuwon Okubena, the man behind the JOBELYN STORY to tell the story himself. Beautifully, he tells it beautifully, with some editing by me, in following words….

    THE STORY BEHIND JOBELYN (1)

    This website has the objective of telling the story of a herbal product that was developed from African folk medicine which had been in use for centuries by people of South western Nigeria to treat and cure diseases of diverse origin, including anaemia, diabetes, hypertension, cancer, arthritis and HIV. For a start, the story teller is Olajuwon Okubena. He was born at Ilese – Ijebu located in Ijebu North East Local Government of Ogun State, Nigeria three years into the Second World War. My early life up to the age of 15 was spent in my home town.

    By the year 1957, I left my home town to attend a Teachers’ College at Sagamu for four years and qualified as a Grade Two Teacher in 1960. The first four years of my career was at Ijebu-Igbo in Ogun State where I was a teacher at the Local Authority Secondary Modern School. I was quite aware that my parents could not afford to support me for a post-secondary education and therefore decided to explore the option of private studies to acquire some further education. The first three years of my teaching career were also spent on private studies which led to my being qualified as an incorporated secretary. I spent 1965 at Oyo town as one of the pioneer teachers in a newly established institution called Ladigbolu Grammar School, Oyo and by that time had commenced writing the exams of the Institute of Cost and Works Accountants (U.K.) . In 1966, I moved to Lagos to take up appointment as the vice-principal of Nigeria Premier College, Yaba (now Jibowu High School). In 1967, I completed the final examinations and by that time the institute had changed to Institute of Cost and Management Accountants. To gain practical experience in accounting, I took up appointment with the United Africa Company (U.A.C.) and was posted to one of their associate companies, Guinness (Nigeria) Plc. I spent the next seven years working for this company until 1974 when I took up appointment with Peat, Marwick, Mitchell & Co. (now KPMG). Having worked for this company for about 10 years, I opted to go into private business and became a farmer producing day-old chicks and poultry eggs.

    A big turning point in my life occurred in 1993 when an attempt was made on my life while residing at the farm house located at Ilese-Ijebu, my hometown. I managed to escape an assassination attempt on my life during the night of August 17 of that year. My attempt to unravel the mystery behind the attack led me to discovery of a herbal preparation which I was not aware will have a great impact on the history of medicine in the whole world.

    I apprenticed myself to a metaphysician to gain more insight into the deeper mysteries of life after surviving the attempt on my life towards the end of 1993. In the course of my tutelage, I observed that my mentor was running a natural health clinic where only one medication was being used to treat and cure all diseases. I was a witness to the miracle being performed with this medication. The clientele cut across the whole spectrum of the society. Doctors, professors, nurses attended this herbal clinic and obtained excellent result in matter of days. I could still recollect that a professor who later became a Minister of Health was cured of leukemia within a period of three months. My major area of focus was to learn metaphysics but I could not help being mystified by the wonders that I was witnessing being performed by the application of this herb.

    Taking a closer look at the healing process in this clinic, I observed that the main herb being used was from the plant of Sorghum bicolor called Poroporo Oka Baba in Yoruba. The liquid extract was obtained by boiling but the colour which was supposed to be bright red was usually presented to patients in assorted colours to disguise the true and natural colour. I could not help confronting my teacher to confirm that it was the same product that was being disguised and presented in different colours. But how could the same herb treat hypertension, diabetes, sickle-cell anaemia, stroke, cancer, arthritis and other diseases? The record of Genesis in the Bible which commenced by saying that the spirit of God was hovering over the waters. It was from this river that God took the sediment to create human structure and the water ( which was reddish ) was injected into human body before God breathed into us to energise us and became a living being after his likeness. According to my teacher, there were plants that grew at the surrounding of the river which were supposed to rejuvenate by virtue of its affinity to the source of our creation. This was what had been revealed to humanity and the use of which was to make human beings to live almost forever. But man was careless and forgot this knowledge. From the time of Methuselah where life span was up to 1000 years, things deteriorated to the present time where average life span in the developed world is about 75 and in the poor countries, 45 or below. When God created everything including man, everything was perfect, but why did things go awry and deteriorated? Periodically, God always looked down upon humanity to provide the path to redemption and restoration and so He decided that the secret to restoration had to be revealed at the beginning of this century and so in preparation for this, the knowledge was purposely revealed to the Yoruba race as part of their folk medicine, decades before the commencement of the new century.

    My teacher became the custodian of this great secret 20 years before I met him, but he was not appointed to develop it for the widespread use of humanity. That was a task that God appointed me to do. On August 17, 1993, I was attacked in the night in my farm house at Ilese-Ijebu and shot in the head. I managed to trek through the forest to seek assistance and I was helped to Ijebu-Ode General Hospital where I could only received first-aid treatment and my loyal friends arranged for my transfer to Ogun State Teaching Hospital, Sagamu where I received further treatment. There was clear evidence that the assassins who attempted to eliminate me were still trailing me and the loyal friends decided to move me to Lagoon Hospital at Apapa. The first X-ray showed that I had about 60 pellets buried in my head as a result of the gun shot received during the attack. The hospital was not sure how to go about my treatment because an attempt to remove the pellets buried in the various corners of my head could be fatal. While this confusion was still on, another friend came with two herbalists who used the traditional means to suck out most of the pellets and declared that the rest would be harmless and they still remained in my head till today.

    I left this hospital after about a week and was lucky to be accommodated by another family friend for about two months before I was moved away for fear of being traced to the place. I spent the next two months at an estate located in Ijebu-Ife and recuperated a lot at that place. Thereafter, I visited many places to unravel the mystery of this attack and I was introduced to a man at Ibadan who was a metaphysician. I was impressed about his vast knowledge of metaphysics because it was an aspect of life that interested me in my youth and had pursued it theoretically. I then had the opportunity to meet a teacher who could give me the practical part of metaphysics that may assist in making life more meaningful to me.

    I apprenticed myself to him for a period of about two years during which time I was visiting his office at Ibadan twice every week to receive lectures. In the course of this, he revealed to me the origin of creation which corroborated the account given in the first book of Genesis in the Bible.

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

  • Tunis study suggests Jobelyn can cure HIV disease

    Does the Human Immuno Virus (HIV) disease exist, or is it a Euro American political, economic and medical game plan to steal about 300 American Dollars every year from poor nations? This question has been asked for decades since researcher Robert Gallo claimed he discovered the virus and later ate his words but became unable to persuade the world that HIV does not exist.

    Like French chemist, Louis Pasteur, Gallo may therefore, be struggling with the burden of resetting the hands of the clock. Pasteur was probably driven to find the cause of disease after three of his five children were killed by typhoid fever. He propounded the Germ Theory of Disease which says germs cause disease and was immediately greeted with controversy. Some researchers, eminent like him, thought that germs did not cause disease. But Pasteur was popular with the media and his voice drowned theirs. His theory did not explain why two persons who are exposed to germs react differently, one becoming sick, the other hale and hearty. In Alternative Medicine today, germs are not seen as the cause of disease. Rather, as the opponents of Pasteur said in those days, it is the failure of the immune system which makes germs gain the upper hand. Staphylococcus aureus, for example, is a commensal bacterium. That means it is a natural inhabitant of our bodies. It overgrows its bounds and make us sick when our immune system is unable to contain it. The same is true of Candida, other bacteria and yeast and viruses which have been linked to all sorts of cancers. By improving the quality of the internal environment and boosting immune function with diet and food supplements, these unwanted guests retreat and we regain radiant health. The Germ Theory of disease, on which the practice of orthodox medicine is grossly based, seeks instead to fight the germs with drugs poisonous to them and the body as well. The germs may be wiped off in this battle alright, but don’t they return soon after with strains resistant to these drugs, which is why many diseases, including cancers and HIV, appear incurable? Do these drugs not leave behind toxic residues which weaken the liver, kidneys and the blood, for example, and thereby, further compromise the immune system, paving the way for the germ to triumph?

    Anyone who has followed these arguments with an open mind, would most likely pitch his or her tent with the idea that the HIV does not exist and the so-called disease is curable. I have seen many HIV – challenged people bounce back to radiant health when they take anti-viral herbs and make dietary and lifestyle changes. My journalism colleague, Mr. Adagbo Onoja, a public spirited community leader, has been helpful to a man who supported his upbringing. Thus the man resident somewhere was discharged from hospital with a CD4 count of 13. In three weeks of taking these herbs, the CD4 rose above 40 and the viral load crashed. My pet friend in Edo State thought she would die after her husband, infected by his girlfriend, died. He had infected his wife with about 120. Today, her CD4 count is well over 800 and she has gone to University and taken a degree. The Nigerian Military hospital at Ikoyi, Lagos, did a Jobelyn study with HIV-challenged soldiers supervised by Dr. Era. It proved so successful that the findings were presented in a paper at a world military hospitals conference held in Bethesda, United States.

    Today, the Nigeria Police uses Jobelyn as well. In Tunis, the Jobelyn study was done by the Gafi Research Institute of Tunis headed by Chamakhe Maurieni. In the interview below, PRAVDA interviewed researcher CHAMAK MAURIENI, of the GAFI RESEARCH INSTITUTE, Tunis, which undertook the Jobelyn study on HIV/AIDS. He is so concerned about what he calls the HIV/AIDS fraud that he devoted more energy to it in the interview, than he did on the Jobelyn research, which he mentions in passing. If this Nigerian herb formula is said to have cured thousands of people challenged with HIV/AIDS far away from the shores of this land, it should be worth the while if the Nigerian government will show interest in the details. After all, with the United States not importing crude oil from 2015, which means about 40 percent of Nigeria’s petrol earnings are threatened, with five African countries in a position to export crude oil at that time, thereby creating a glut in a diminishing world market and with the Jonathan Administration searching for Nigerian herbs to sell to the world. Jobelyn may be heaven sent for this time. Chamakhe Maurieri, please take the floor…

     

    AIDS: 21st century’s biggest fraud

    Chamakhe Maurieni, of the Gafi Research Institute, Tunis, has some very striking revelations about HIV/AIDS, something he calls a “fraud” which feeds “a 300 billion dollar industry” which rests on flimsy evidence that HIV caused AIDS, which, he claims, is not a disease but rather a “state”. Timofei Belov (Pravda.Ru) interviewed Chamakhe Maurieni.

    Pravda.Ru: Chamakhe, you work for the secretive Gafi Research Institute, Tunis and your latest investigation has been on AIDS. Congratulations on having been appointed the lead writer for the Institute. What do you have to reveal to us?

    CM: It is simply a hoax, the Gafi research team termed it the 21st century’s greatest fraud. The HIV/Aids industry is a 300 billion-dollar industry of manipulative fraud, lies, deceptions, more lies and many more lies. From a ploy by a few people running into hundreds, it has risen over two decades and has been invested in by private individuals, co-operations and various governments across the world. It’s simply been used over and over to balance government corrupt books.

    What kind of weapons shoots blanks? Whoever proved HIV CAUSED Aids? The answer is a big gaping Nobody. Ask yourself a question majority of the world population, including the so-called HIV patients, have never asked themselves or put to world governments, organisations, NGOs who go about preaching HIV kills, safe sex and a host of other sickening slogans. Where are the scientific references establishing HIV as the cause of AIDS? Presently, there are none.

    Pravda.Ru: What do you mean? What about all the research carried out by the world’s top professors?

    CM: If you think a virus is the cause of Aids, do a control without it; this has surprisingly never been done. The current epidemiology of Aids is simply a pile of anecdotal stories, selected to fit the AIDS hypothesis. The HIV/Aids story is a multi-billion/dollar/pound fraud, racket which is based on two fallacies: Aids is a single disease/aids is a disease and secondly that Aids is caused by the HI virus or the HIV VIRUS as some choose to call it – perhaps they think V in HIV stands for volcano.

    Taking a look at the fallacies, fabrications; it need be stated: Aids is not a single disease but rather a state where the immune defence system in a human is, simply put, DEAD, WEAK, INEFFECTIVE…

    Thus, the said human is vulnerable to every form of disease attack, it can be Malaria, measles, papilloma and so much more… The second fabrication claims Aids is caused by HI, which is false. HIV is a retrovirus, a retrovirus is an RNA virus duplicated in a host cell using the reverse transcriptase enzyme to produce DNA from its RNA genome. Retroviruses are unlike flu viruses, they don’t cause diseases HIV…..is one thousandth the size of a regular cell. HIV is simply a harmless piece of dead tissue, not unlike the numerous other retroviruses which exist in the human body. Thus, it is not even probable, let alone scientifically proven, that HIV causes AIDS. If there is any such real evidence, there should be scientific documents which demonstrate the fact,…..right now , presently, at the moment, there are no such documents. All we have at the moment are hear-says, fictitious stories, lies and mere-propaganda by the mainstream media.

    A major problem with the AIDS definition is that it ignored the man-made environmental causes of immune suppression. Exposure to toxin, alcoholism, heavy drug use or heavy antibiotic use; all of these can cause an onset of the list of diseases which provide the same symptoms/identical symptoms indicative of AIDS.

    The HIV/Aids propagandists all intentionally forget to inform the world that HIV positive response in humans can be triggered by vaccination, malnutrition, measles, influenza, papilloma virus, war, leprosy, hepatitis, syphilis and over forty different other conditions.

    Pravda.Ru: Let us follow the course of AIDS through from the beginning.

    CM: Let’s make a brief history of how all of these HIV/Aids lie came to be. It all emerged from the USA and that should be common knowledge I presume. The truth is simple but has been kept for too long. Previously to the announcement by Robert Gallo, head of a retrovirus lab at the National cancer institute, at a 1984 press conference, that HIV causes Aids, it all began with Federal centres for disease control and prevention, overstating their relevance and were thus under threat of being disbanded. The centre needed a serious epidemic to justify its continued existence, it decided to name Aids as a single contagious disease and thus created an atmosphere of public fear, and panic, which brought it increased funding and power. Simply put, public fear of a new dreaded AIDS was used as a catalyst to achieve increased power and funding.

    After the announcement by Robert Galo, head of a retrovirus lab at the national cancer institute in 1984, pharmaceutical companies by a decade later, began exploiting the situation by bringing back highly toxic, failed cancer drugs-AZT, it is also called Zidovudine or Retrovircombination Therapies. These drugs have been proven and were proven once more by various scientists, in the past, and also proven by the Gafi research institute, to destroy the immune system and cause the same symptoms attributed to HIV.

    This has been known and stated by researchers such as Peter Duesburg, professor of Biochemistry and molecular biology at the University of California at Berkeley, and by Nobel prize winning scientist Walter Gilbert. These two researchers also questioned the reality of the ‘ HIV causes Aids’ story, but instead of being urged-on in their attempt to help mankind, they were ridiculed and their funding was stopped by the powers that be.

    Pravda.Ru: So much for the individuals. Now for the pharma industry…

    CM: We are beginning to get somewhere. Let’s take a brief look at the industry which claimed to have found AIDS – This key research had been investigated for scientific fraud by powerful American scientific institutions and by the American congress between 1990-1994, when an enquiry was conducted into this research, which claimed to have discovered Aids.

    The enquiry reported lots of major errors in the research, with some errors so serious that it became impossible to repeat the key HIV experiment and verify the findings. Conducting the research again would simply have exposed the entire Aids lie. In proving the fraud present within the HIV/Aids storyline, researchers at the Gafi institute examined 950 Aids positive patients and another 950 patients who were Aids negative.

    Testing these two distinct groups of patients using Electron Microscopy test on the two groups revealed retroviruses -like particles in 95 percent enlarged lymph nodes from the Aids patients. Using electron Microscopy test on the other group of 950 patients who are not infected with AIDS, the research team discovered the same identical particles in 95 percent of enlarged lymph nodes from this group of patients, who are Aids negative, and were not at risk of developing Aids.

    Thus, if the particles seen in the AIDS patients, are as Aids experts assure – HIV, then what were the particles found in patients who were not Aids positive and were not even at risk of developing Aids? The research team sensed a higher push behind this entire HIV/Aids hoax.

    The research team discovered a 300 billion-dollar AIDS industry. I choose to call it the Aids racket or the money-spinning machine.

    Pravda.Ru: And who is behind this?

    CM: This racket includes Governments, pharmaceutical companies such as Glaxo/Borough Wellcome – MANUFACTURER of AZT, the condom industry – if you choose to differentiate it from the pharmaceuticals, celebrities, NGOs and the list goes on.

    The condom industry is worth an estimated thirteen billion dollars presently, and this turns out to be big money. Our research showed 82 percent of condom users buy condoms solely as a result of the fear of contacting Aids. Meaning of every one thousand condom buyers,

    820 of these buyers make the decision to buy a condom because of the fear of AIDS.

    You can put this to yourself… without the whole HIV /Aids hoax or better still, if the world realises the truth behind the whole HIV hoax, the condom industry stands to lose 82 percent of its customers; in financial terms, it loses 82 percent of its thirteen billion dollar worth. With this to play for, the condom companies will continue to share around the Aids hoax.

    The pharmaceutical companies for their part are responsible for breeding and increasing the number of immune deficient patients around the world, most especially in Africa. The AZT which is a major drug sold by pharmaceutical companies like Glaxo/Borough Wellcome was found to destroy the immune system, thus allowing the human body to develop identical systems indicative of Aids.

    AZT was found by our research team and even by American toxicologist and pathologist- Ali Al-Bayati Ph.D. to be responsible for the following diseases/conditions, among others: neutropenia, granulocytopenia, anemia, thrombocyte, nail pigmentation, sinusitis, acne, dyspnea, mouth ulcer, body odour, hyperbilirubinemia, vasculities, lactic acidiosis, sensitisation reactions, myositis, heptamegaly with steatosis, syncope, edema of the tongue, cough, abdominal pain, back pain, pancreatitis… amongst a list of many others.

    Other Aids drugs such as Nevirapine, protease inhibitors and Arts have adverse effects similar to that of the Azt drugs. These drugs ensure users are dependent on them for life, failure to use those results in an almost instant death. There are thousands of people who have been diagonised with Aids, and have courageously refused Aids medication. Our research team came across hundreds of such people, amongst them being GOLDIE GLITTERS, who has lived for 30 years after being declared HIV POSITIVE. In his own words, he said:

    “I have known so many people who have died of aids…. and all of them took the drugs prescribed by doctors….I have never taken any of these drugs and I haven’t gotten sicker. Not even a cold. The doctors told me I had just five years to live….I have lived 30 years since then.

    “These drug companies producing the aids medications are getting very rich….everyone I know who were HIV positive and taken the aids medication, have all died after taking these drugs, and that is a whole lot of people”.

    Pharmaceutical companies are in the driving seat in terms of increasing the so-called AIDS patients, around the world. THE MORE THE NUMBER OF PERSONS DOWN WITH DESTROYED IMMUNE SYSTEMS, THE MORE THE PROFIT. That is the HIV/AIDS rule.

    Pravda.Ru: You mentioned Governments?

    CM: Governments have many times become the biggest benefactors of this racket. Top government officials in many countries across the world know and do have an idea about the AIDS fraud. They know AIDS is not a disease, but a state of the body, they know HIV doesn’t result in Aids, but they continue to budget billions, millions depending on the government in the name of research programmes, awareness……

    The biggest beneficiary of this AIDS racket is the American government. Using platforms like PEPFAR, they exploit unsuspecting countries across the world. PEPFAR focuses mainly on fifteen countries presently, which include: Botswana, Ivory Coast, Ethiopia, Guyana, Haiti, Kenya, Mozambique, Namibia, Nigeria, Rwanda, South Africa, Uganda, Vietnam and Zambia.

    These are believed to be countries with some of the highest numbers of cases of AIDS infections, but in true sense these are the countries whose governments benefit wholesomely from the Aids fraud and have allowed for the AIDS fraud to be used as a pretext for exploitation.

    In a country like Nigeria, the American government provides ARTS,AZTS in exchange for unrefined crude oil, the Gafi research team has got evidence to back this claim.

  • Jobelyn’s American journey

    YEARLY, fast growing entrepreneurs cutting across board gather in the United States (US) for the AllWorld Network Summit.

    This year’s, the fourth in the series, was held at Harvard University in Cambridge, Massachusetts, US, last month.

    Health Forever Product (HFP) Limited was among the over 70 firms from Saudi Arabia, Jordan, Pakistan, the United Arab Emirates (UAE), Turkey, and Nigeria that participated in the Harvard summit before travelling to New York City for additional networking meetings.

    Each participant is a winner of AllWorld rankings in emerging countries and is among a select group of entrepreneurs from 15 countries invited to attend the summit.

    During the summit, participants attended interactive sessions led by some of the leading national and international experts on business development, global sales strategies, breakthrough technologies, behavioural economics and negotiating conflicts. Co-founder Habiby opened the summit.

    As a group, entrepreneurs attending the summit pulled an astonishing 60 per cent annually over the past three years and created thousands of jobs while the world’s economy stagnated. In 2013 to 2014, they expect sales and employment to rise significantly and two-thirds expect to establish another company.

      HFP represented by Mr Ademola Okubena, an executive director of the company, was among the 10 successful AllWorld Entrepreneurs who gave two-minute pitches.

    Ademola introduced HFP as a manufacturer of a dietary supplement under the trade name, Jobelyn. The company is the leading nutraceutical company in Nigeria and is Nigeria50 ranked.

    Jobelyn is one of the few African products recognised by the United States Food and Drug Administration (FDA).

    The world including the US has not found a satisfactory solution to the problem of anaemia, but HFP has developed a herbal formula from the African folk medicine to provide a solution.

    HFP employs 100 staff. Over the last 15 years, HFP has through intensive scientific research into African folk medicine developed Jobelyn certified as the solution to anaemia in addition to being the most powerful antioxidant in the world (about four times more powerful than the Acai berry, the leading American antioxidant product)

     Jobelyn has more than five million users in Nigeria and it is projected this figure would increase to 15 million in the next three to five years. It has provided an affordable option for blood transfusion which has complicated the spread of deadly diseases like HIV. It has also provided good support for malnourished children in developing countries like Nigeria and other African countries.

    The US has so far not been able to develop a satisfactory solution for the problem of anaemia and our main focus for international expansion therefore is USA. Our estimate is that Americans expended a minimum of $10 billion annually for the treatment of anaemia with orthodox chemical drugs that have dangerous side-effects. We want to target at least one per cent of this in the next five years. This would translate into a yearly income of $100 million.

    With the right investment, our company is set to grow its revenue, which is about $2 million to over $100 million in the next five years thereby providing substantial return on investment to stakeholders.

    Hains Herbal LLC, the U.S. subsidiary of Health Forever Product Limited, was incorporated in 2002 in order to expand and capture the US market. The company was formed with a specific focus on marketing and distributing the range of alternative herbal preparations manufactured by HFP in the US.

    Since inception, HFP’s main focus has been to provide its clients with the highest quality herbal medicines and dietary supplements. Through continual research into primary causes of ailments, the company has been able to identify and develop herbal remedies to assist the human body to fight against and prevent the causes of so many life threatening diseases.

    The medicines and products have been subjected to orthodox clinical studies and have proven, in a number of cases, more effective and tolerable than orthodox alternatives.

    The presentation was well received and HFP has been receiving enquiries from prospective investors.

  • Jobelyn linked with psychosis treatment

    Director, Health Forever Products Limited, Lagos, Bimbo Okubena, answers the first question based on the research published in the Journal of Basic Clinical Physiology and Pharmacology. Dr Segun Fahuwa answers the second from his Mister Guarantee Trado-herbal Clinic, Surulere, Lagos.

     

    psychosis is a neurological disorder and a serious medical and social problem in most African countries. Individuals with psychotic illness tend to seek help from traditional medical practitioners, who prescribe herbal remedies as an alternative form of treatment for the disease.

    Although hyperdopaminergic activity is generally believed to play a crucial role in the symptomatology of the disease, most Africans believe the disease is due to supernatural forces at work against the mental well-being of individuals, and as such, the cure cannot be found in modern medicine or orthodox medical practice. The scarcity of accessible and high quality mental health care services in most African countries also contributes to the increased patronage of traditional healers by patients with psychotic disorder.

    Jobelyn (JB) is a commercial poly herbal formulation that has been studied to show beneficial effects in neurological disorders. Although it is being prescribed in many Nigerian hospitals including the Yaba Psychiatric Hospital in Lagos, however, its usefulness in psychosis has not been scientifically validated.

    This prompted a study /research to evaluate its effects on animal models predictive of human psychosis.

    Three researcher went to work Itivere Adrian Omogbiya,. They are Adegbuyi Oladele Aderibigbe and Adewale Ganiyu Bakre, Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria. They concluded that JB exhibits antipsychotic-like activity, devoid of the adverse effect of cataleptic behavior, and may offer some beneficial effects in the symptomatic relief of psychotic ailments.

    Permit me to go a bit technical in the analysis of the animal model because of the intricacies of the Science involved.

    Methods: Antipsychotic activity of JB was assessed based on the inhibition of stereotyped behaviour induced by amphetamine or apomorphine in mice. Ampheta-mine-induced hyperactivity and lethality in aggregated mice were additional tests employed to further evaluate the antipsychotic property of JB. The effect of JB on catalepsy was also assessed, using the inclined plane paradigm.

    Results: JB (5 – 50 mg/kg, p.o.) significantly (p < 0.05) inhibited stereotype induced by amphetamine (10.0 mg/kg, i.p.)or apomorphine (1 mg/kg, i.p.), which suggests antipsychotic activity. Furthermore, JB (5 – 50 mg/kg, p.o.) reduced lethality in aggregated mice and inhibited hyperactivity induced by amphetamine, respectively. However, JB (5 – 50 mg/kg, p.o.) did not cause cataleptic behavior, as it failed to alter the duration of stay of the animals on the inclined plane.

    Treatment: Dunnett post-hoc test was found to specifically antagonise grouped AMP (Activated Protein Kinase) toxicity at dose levels which had little effect on the toxicity of AMP to isolated mice. Protection against the lethal effect of AMP to grouped mice has therefore been considered as a suitable test for assessing substances with antipsychotic effects. Although it has been shown that the LD 50 of AMP to grouped mice is dependent both on environmental temperature and degree of aggregation of mice, the underlying cause for greater toxicity of AMP to grouped mice is not yet fully understood.

    However, it has been suggested that the major events leading to death in grouped mice, given AMP, is closely connected with marked hyperactivity, followed by a phase of exhaustion in those mice which died. Previous studies have shown that a significant association exists in grouped mice between increased lethality and increased motor activity. However, Burn and Hobbs reported that increased excitement may be the critical factor in enhanced lethality of AMP to grouped animals. Hyper-activity or agitation and displays of aggressive behaviors are integral components of psychomotor excitement commonly seen in most patients with psychotic disorders.

    Patients in the state of psychomotor excitement constitute sources of danger to themselves and others, thus requiring the use of drugs with a tranquillizing effect such as antipsychotics. The finding that increased dopamine brain levels is the major neurochemical pathway involved in the mediation of the lethal effect of AMP in grouped mice further support its relevance as an animal model predictive of antipsychotic activity.

    Studies have shown that stereotypies induced by high doses of AMP or APO (Alpha Phi Omega) are mediated through the stimulation of dopamine D2 receptors in the striatum.

    However, whereas APO mediates its action through direct activation of dopamine receptors in the striatal region of the brain, AMP, by contrast, acts indirectly through the liberation of dopamine from dopaminergic neurons.

    The neurochemical mechanism underlying AMP-induced hyperlocomotion or hyperactivity at moderate doses is closely connected with the activation of dopamine D2 receptors located in the limbic region of the brain.

    Thus, preferential blockade of D2 receptors in the limbic system will confer antipsychotic effects with little or no propensity to cause extrapyramidal symptoms (EPSs).

    EPSs are thought to result from decreased dopamine activity in the striatum, a preferential action of a novel agent against AMP-induced hyperactivity might serve as an earlier indicator of a lower propensity to induce EPSs in patients. Although first-generation or typical antipsychotics such as HP inhibit AMP-induced hyperactivity and stereotypies, the atypical counterparts.

    Conclusions: Taken together, these findings suggest that JB exhibits antipsychotic-like activity, devoid of the adverse effect of cataleptic behavior, and may offer some beneficial effects in the symptomatic relief of psychotic ailments.

    This study shows that Jobelyn  demonstrated antipsychotic activity devoid of the cataleptic effect of traditional neuroleptic agents and this may be suggestive of a preferential antagonism of D2 -mediated dopaminergic activity. For further enquiries visit: www.afritradomedic.com  or send email to okubena@health-forever.com.

     

  • Jobelyn rebrands

    Jobelyn rebrands

    Health Forever Product Limited, manufacturers of the acclaimed herbal/dietary supplement, Jobelyn, has rebranded the product to protect it.

    The action was informed by what the firm called the faking of the product.

    The 30-capsule and 100-capsule packs have been rebranded; they are now in olive green colour background. They used to be white. The surface of the blister foil is now in two colours, i.e., green and black fonts.

    According to its Managing Director, Otunba Olajuwon Okubena, customers are advised to return the old packs to where they bought them or to the company at 11, Dipeolu Street, Off Obafemi Awolowo Way, Ikeja, Lagos to be exchanged for the new packs not later than two weeks from today.

    “Health Forever has decided to make Jobelyn available to all pharmaceutical shops across the country on demand and orders could be taken through our telephone numbers, 08035657284, 08078516953 and 234-1-881966 and e-mail, orders@health-forever.com. Customers are requested to complete our application forms for accreditation,” he said.

    The company said Simba Pharmacy at 18 Church Street, Idumota is the only accredited distributor for Idumota drugs market, Associated Innokings Pharmacy for Onitsha Drugs Market, Chuks International Merchants Co. for Aba Drugs Market, and Mark Etim of 65 Abak Road, Uyo for Akwa Ibom and Cross River States.