Tag: scientists

  • Vegetables, fruits, others vital to life, say scientists

    Which meals are good for the body? Meals that are rich in nutrients and fibre, say Unilever scientists in the report of a cinical study. Such meals, they said, could also help combat obesity and type 2 diabetes.

    The scientists presented their preliminary findings at the 20th European Congress on Obesity in Liverpool. The study compared two meals using readily available ingredients, a healthy modern meal and a Palaeolithic age-inspired meal, which is so called because its composition mirrors a range of foods that people have easy access to in the olden days.

    The scientists compared a healthy modern meal comprising fish, rice, one portion of fruit and one portion of vegetables with a Palaeolithic-inspired meal comprising fish, no rice, a broad variety of different fruits and vegetables, nuts and mushrooms. All the meals contained the same amount of protein, fat, carbohydrates and calories.

    The Paleolithic-inspired meals are majorly Phytonutrients. Phytonutrients are bioactive plant-derived compounds often associated with a range of positive health effects. Some phytonutrients are orange colour- squach, mango, carrots; red/purple colour- grapes, cherries, strawberries; orange/yellow colour- orange, pineapples; green/yellow colour- avocado, spinach, green beans; red colour- tomatoes, watermelon; green colour- brocolli, cabbage, dark green vegetables; brown colour- nuts; white colour- coconut, maize.

    Also incorporated in them, and a broader range of plant- based foods like nuts and spices such as cinnamon in addition to fresh fruit and vegetables.

    The metabolism of these are used for the experiment, and was monitored three hours after eating and those that consumed the modified meal felt much fuller.

    The results also showed that they had significantly higher levels of PYY, a hormone that tells the brain that a person has had enough to eat.

    Explanatory reasons for the results include that the Palaeolithic-inspired meal had a low energy density resulting in a physically bigger meal for the same amount of calories than the modern meal. This could account for the increased satiety levels. The meal was also designed using plant-based ingredients chosen to be both high in fibre and rich in phytonutrients.

    Prof Mark Berry, Senior Scientist at Unilever who led the research said: “Initial findings from our study suggest we might do well to get back to basics and eat a diet for which our bodies have evolved. With its mix of lean meat, fresh fish and a very broad variety of plant-based foods, our ancient ancestors’ diet was different from what most of us consume today. Furthermore, the human genome has not had time to respond to radical recent changes in our diet and therefore human physiology is at odds with the vast majority of modern diets.

    “The great thing is we didn’t have to invent a time machine to do this study – all the ingredients needed for the Palaeolithic-meal could be readily purchased.”

    Prof Gary Frost from Imperial College London said the initial findings could have other profound benefits: “Up to now surgery has often been the only viable solution to tackle chronic obesity but this research has exciting future possibilities of opening up a genuine alternative to gastric surgery. The observation that Palaeolithic diet leads to an increase in PYY raises the possibility of designing a diet that would act as a sort of nutritional bypass.”

    Dr Frances Bligh, Lead Scientist at Unilever said the team now plans to work with academic colleagues to investigate some of these effects further. “We want to see if the findings could be applied to foods of the future,” he stated.

     

  • ‘Nigerian scientists have failed woefully’

    ‘Nigerian scientists have failed woefully’

    Professor Oyewale Tomori, a renowned virologist, has earned many plaudits both nationally and internationally for his contribution to the field of virology. Tomori, who is a former Vice-Chancellor, Redeemer’s University and current president, Nigerian Academy of Science, a foremost science institute in the country, has been leading the campaign against polio eradication for decades. In this interview with Ibrahim Apekhade Yusuf, he shares his concerns on the polity. Excerpts:

     

    You have been in the forefront in the campaign against polio eradication these past decades. How far are we close to winning this war?

    Nigeria’s eradication campaign faces substantial challenges. However, we can say that we have made remarkable progress. This year, we expect nearly 50percent drop in cases in 2013 compared to last year.

    But thankfully, the Eradication and Endgame Strategic Plan was shared at the Global Vaccine Summit in Abu Dhabi, where world leaders showed their support through a series of historic commitments, including the UK’s Department for International Development commitment of £300 million. The Gates Foundation pledged US$1.8 billion, and a new group of philanthropists committed an additional total US$335 million.

    His Highness, General Sheikh Mohamed bin Zayed Al Nahyan, Crown Prince of Abu Dhabi and Deputy Supreme Commander of the UAE Armed Forces, pledged US$120 million

    Qatar Charity and the Gates Foundation signed a co-operation agreement in support of the eradication effort.

    The Global Vaccine Summit in Abu Dhabi which held from April 24-25 2013, was hosted by the Crown Prince of Abu Dhabi, Bill Gates and the UN General-Secretary. The Summit endorsed the critical role that vaccines and immunisation play in saving lives and protecting children from preventable diseases such as polio. The Summit is expected to continue the momentum of the Decade of Vaccines – a vision and commitment to reach all people with the vaccines they need.

    The new commitments make clear the confidence of global leaders and the vaccine community in the new plan’s ability to both achieve a lasting polio-free world by 2018 and help build systems that will deliver critical health services, including vaccines and maternal healthcare, to those most in need. The commitments bring the world almost three-quarters of the way to the US$5.5 billion needed to fully fund the plan.

    As at the last count, a total of $3billion has so far being raised leaving a shortfall of $2.5billion.

    The endorsement of the Global Vaccine Action Plan by the World Health Assembly which again set 2018 as the new target for the global eradication of polio saying Nigeria must ensure that no single case of polio is reported anywhere in the country by 2014.

    The hope is that by the year 2014, the world will have the last country with the last case of polio and by 2018, the world will be declared free of polio.

    Is 2014 realistic as far as Nigeria is concerned?

    Presently, northern region specifically constitutes major concern for global polio fighters, who now worry over the quality of local personnel and efforts. At least, 12 per cent of the Northern children population is said to be left out of polio vaccination due to numerous issues, including itinerancy, security challenge and other socio-political concerns.

    But to answer your question, I think we are taking a gamble because the year 2014 is only subject to the fact that Nigeria, Afghanistan or Pakistan (the only three remaining endemic countries) will not have any case of polio in 2014. If we do have any of these countries having one case by 2014 it means we have to shift the year of eradication by an extra year. It is thus very important that we, as a country, must play our role, otherwise, we will be holding the world back.

    But the question to ask again is, why should we be the last? Why can’t the Federal Government and other tiers of government for instance, accord polio eradication the kind of priority given the spate of flood disasters in some parts of the country where President Goodluck Jonathan personally garnered support from individuals and corporate bodies?

    Has our President ever said anything on polio without stimulation from outside? The only time we’ve heard him make pronouncements are when he was invited by the Commonwealth, the United Nations or when Bill Gate came. We are not putting enough into polio eradication.

    We need education. We need to get our people to know the advantage of immunisation; we need good leadership and community involvement. Nobody should be left out of the fight.

    Imagine Bill Gates the other day was bearing a list of state governments in Nigeria doing little or nothing to curtail the malaria epidemic. It is a shame. After all, we don’t need outsiders to tell us how many children to give birth to so why do we have to wait on them to take care of these same children for us? It doesn’t speak well of us at all.

    Do you think the recent killing of vaccinators in northern part of the country can adversely affect the campaign against polio eradication?

    The killings drew comparisons with a series of incidents in Pakistan last December where five female polio vaccinators were gunned down, apparently by Islamist militants. It also signalled a fresh wave of hostility towards immunisation drives in the country, where some clerics have claimed the vaccines are part of a western plot to sterilise young girls and eliminate the Muslim population.

    So to answer your question directly, the sad episode is certainly a setback for polio eradication in Nigeria, but not a stop. The best we can do is to work harder and see the end of polio … so their loss will not end as a useless sacrifice.

    But like I have always advised, the war against polio should not be fought in isolation. We all must be involved.

    There are lots of misconceptions and stereotypes about what the north wants and do not want. There is need for understanding. For instance, how do you expect a family which has just lost a loved one to the cold hands of death say through measles, happily come out to partake in vaccination? These are some of the issues. Unless we understand these peculiarities, we will continue to go round and round the circles.

    If you go back in time, you will recall that the polio vaccine boycott which started in Kano in 2003 was as a result of the now famous Pfizer’s Trovan clinical trial scandal in 1996. But what we are yet to find out is who gave approval for the clinical trials? Certainly, approval didn’t come from outer-space, someone, somewhere gave the approval. But there has been a lot of blame game here and there.

    Is Nigeria still one of the countries in the yellow fever belt?

    Of course, Nigeria is one of the 17 endemic countries in the belt. Unfortunately, while every other country in the yellow fever belt had immunised their citizens against the disease, Nigeria remains the only country yet to embark on mass vaccination against the disease.

    But thankfully, the government currently had 66 million doses of the yellow fever vaccine and hopefully, should commence immunisation soon in some endemic parts of the country adding that the quantity could not cover the entire country.

    But we still don’t have enough yellow fever vaccine. There’s a plan to gradually go round the country and there’s hope that by the time we go round the country, the producer would have produced more. There’s not enough but the little that will be available, people should go for it.

    Why can’t Nigeria produce enough vaccine to serve the teeming populace?

    I agree it’s a big shame that Nigeria relies on other countries in the world for its vaccine needs. As I’m talking to you now, I know for a fact that we can’t manufacture reagents. But this wasn’t the case in the 80’s. There’s no reason why Nigeria should be depending on other countries for its vaccine. We had a vaccine manufacturing firm in Yaba, Lagos in 1994 which has gone under. We need to resuscitate it. Is it not lamentable that a country like Senegal is also one of the countries producing vaccine for us?

    But again, a number of factors might be responsible for this. Brain-drain is a major factor. Most of our doctors and scientists, especially my generation, took flight out of the country when government policy practically reduced us into paupers. There was a situation in this country where professors could no longer live decent lives. What do you make of a situation where as a professor you could not have a roof over your head talkless of being able to eat three square meals a day. It was that bad.

    So, like they say the first law of nature is the law of self-preservation. We had to leave in order to maintain our sanity. But then, those we left behind never had the benefit of good mentorship and that is why there is too much dependence on foreign vaccines because you are not so sure of the quality produced locally.

    Is this not an indictment on our local expertise?

    Yes, we all share in the blame one way or the other. In those days, we didn’t have improved techniques but we were able to detect any variant of yellow fever and thus were able to administer the right vaccines. But these days we rely too much on advanced techniques which come with a lot of baggage.

    See what China has done, despite the advancement in science, China for instance, has not done away with its roots.

    Take their traditional medicine, the acupuncture, it has become widely acclaimed. Right now, there is an acupuncture centre in New York. It is good to go back to the roots… China as a country keeps what makes them Chinese.

    Let me also make this point that our scientists have not done creditably well over the years.

    If you look at scientific journals all over the world, what make the news are the scientific discoveries, but what have Nigerian scientists done so far?

    In my acceptance speech at the Academy, I made the point that as professionals we must make our impact felt in the society. Let’s see how we can make a change. My hope is that in the next four years, Nigerian scientists will become more relevant in the scheme of things because presently we have failed the country.

    It doesn’t require a thousand people to change the world, it takes just a few people.

    Little drops of water make an ocean but I always say that you must gather the drops in one place to be able to make the ocean because if the little is scattered, you can’t achieve the utmost aim. Let’s see where each of us has a common purpose and plug our force into that.

  • HIV cure for the first time in a baby, say scientists

    RESEARCHERS say they have, for the first time, cured a baby born with HIV; a development that could help improve treatment of babies infected at birth.

    The only fully cured AIDS patient recognised worldwide is the so-called “Berlin patient,” American Timothy Brown. He is considered cured of HIV and leukemia five years after receiving bone marrow transplants from a rare donor naturally resistant to HIV. The marrow transplant was aimed at treating his leukemia.

    But in this new case, the baby girl received nothing more invasive or complex than commonly available antiretroviral drugs. The difference, however, was the dosage and the timing: starting less than 30 hours after her birth.

    “Prompt antiretroviral therapy in newborns that begins within days of exposure may help infants clear the virus and achieve long-term remission without lifelong treatment by preventing such viral hideouts from forming in the first place,” said lead researcher Deborah Persaud, of Johns Hopkins Children’s Centre in Baltimore, Maryland.

    It appears to be the first time this was achieved in a baby, she said.

    The baby was infected by her HIV-positive mother, and her treatment with therapeutic doses of antiretroviral drugs began even before her own positive blood test came back.

    The typical protocol for high-risk newborns is to give them smaller doses of the drugs until results from an HIV blood test is available at six weeks old.

    Tests showed the baby’s viral count steadily declined until it could no longer be detected 29 days after her birth.

    The child was given follow-up treatment with antiretroviral until 18 months, at which point doctors lost contact with her for 10 months. During that period she was not taking antiretroviral.

    Researchers then were able to do a series of blood tests and none gave an HIV-positive result.

    Natural viral suppression without treatment is an exceedingly rare occurrence, seen in fewer than half a percent of HIV-infected adults, known as “elite controllers,” whose immune systems are able to rein in viral replication and keep the virus at clinically undetectable levels.